Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus

Takahiko Shiina, Yasutake Shimizu, Ammar Boudaka, Jürgen Wörl, Winfried L. Neuhuber, Tadashi Takewaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The enteric nervous system plays a vital role in gastrointestinal smooth muscle motility. Unlike the tunica muscularis of the stomach, small intestine and large intestine, which is constituted entirely of smooth muscles, the external muscle layers of the mammalian esophagus contain striated muscle fibers. These striated muscle fibers are innervated exclusively by excitatory vagal efferents and terminate on motor endplates. It is believed that peristalsis in the striated esophageal muscle is executed according to a sequence preprogrammed in a medullary swallowing network and modulated via vago-vagal reflexes. By contrast, the presence of a distinct ganglionated myenteric plexus in the striated muscle portion of the mammalian esophagus has long been known. However, the role of the intrinsic nervous system in the peristalsis of the striated muscle portion of the esophagus has remained enigmatic, and has been neglected in terms of peristaltic control. Recently, the regulatory roles of intrinsic neurons in the esophageal striated muscle have been investigated. The esophageal intrinsic neurons may compose a 'local neural reflex pathway' and regulate the motility of the striated muscle via influencing the neurotransmission in the motor endplate.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalCurrent Topics in Pharmacology
Volume11
Issue number1
Publication statusPublished - 2007

Fingerprint

Striated Muscle
Esophagus
Motor Endplate
Peristalsis
Smooth Muscle
Reflex
Enteric Nervous System
Neurons
Neural Pathways
Myenteric Plexus
Large Intestine
Deglutition
Synaptic Transmission
Nervous System
Small Intestine
Stomach
Muscles

Keywords

  • Enteric neuron
  • Esophagus
  • Nitric oxide
  • Striated muscle
  • Tachykinin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Shiina, T., Shimizu, Y., Boudaka, A., Wörl, J., Neuhuber, W. L., & Takewaki, T. (2007). Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus. Current Topics in Pharmacology, 11(1), 11-17.

Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus. / Shiina, Takahiko; Shimizu, Yasutake; Boudaka, Ammar; Wörl, Jürgen; Neuhuber, Winfried L.; Takewaki, Tadashi.

In: Current Topics in Pharmacology, Vol. 11, No. 1, 2007, p. 11-17.

Research output: Contribution to journalArticle

Shiina, T, Shimizu, Y, Boudaka, A, Wörl, J, Neuhuber, WL & Takewaki, T 2007, 'Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus', Current Topics in Pharmacology, vol. 11, no. 1, pp. 11-17.
Shiina, Takahiko ; Shimizu, Yasutake ; Boudaka, Ammar ; Wörl, Jürgen ; Neuhuber, Winfried L. ; Takewaki, Tadashi. / Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus. In: Current Topics in Pharmacology. 2007 ; Vol. 11, No. 1. pp. 11-17.
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