TY - JOUR
T1 - Litoarbolide A
T2 - an undescribed sesquiterpenoid from the Red Sea soft coral Litophyton arboreum with an in vitro anti-malarial activity evaluation
AU - Ahmed, Mohammed M.A.
AU - Ragab, Ehab A.
AU - Zayed, Ahmed
AU - El-Ghaly, Elsayed M.
AU - Ismail, Said K.
AU - Khan, Shabana I.
AU - Ali, Zulfiqar
AU - Chittiboyina, Amar G.
AU - Khan, Ikhlas A.
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023/2
Y1 - 2023/2
N2 - Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral Litophyton arboreum led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide A (1), along with 14 previously reported metabolites (2-15). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data. Litoarbolide A is supposed to be the biosynthetic precursor to other sesquiterpenoids, which formed via further post-translational modifications. Furthermore, these metabolites were evaluated for anti-malarial activity, where only the acyclic sesquiterpenoid of a sec-germacrane nucleus (7) showed an activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 at 3.7 and 2.2 mg/mL, respectively. Moreover, the isolated metabolites were all non-toxic to the Vero cell line. These findings support the consideration of L. arboreum in further natural anti-malarial studies.
AB - Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral Litophyton arboreum led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide A (1), along with 14 previously reported metabolites (2-15). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data. Litoarbolide A is supposed to be the biosynthetic precursor to other sesquiterpenoids, which formed via further post-translational modifications. Furthermore, these metabolites were evaluated for anti-malarial activity, where only the acyclic sesquiterpenoid of a sec-germacrane nucleus (7) showed an activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 at 3.7 and 2.2 mg/mL, respectively. Moreover, the isolated metabolites were all non-toxic to the Vero cell line. These findings support the consideration of L. arboreum in further natural anti-malarial studies.
KW - Litophyton arboreum
KW - Soft coral
KW - anti-malarial activity
KW - sesquiterpenoid
KW - Plasmodium falciparum
KW - Animals
KW - Indian Ocean
KW - Sesquiterpenes/pharmacology
KW - Anthozoa/chemistry
KW - Chloroquine/pharmacology
KW - Antimalarials/pharmacology
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U2 - 10.1080/14786419.2022.2071268
DO - 10.1080/14786419.2022.2071268
M3 - Article
C2 - 35491702
AN - SCOPUS:85129264491
SN - 1478-6419
VL - 37
SP - 542
EP - 550
JO - Natural Product Research
JF - Natural Product Research
IS - 4
ER -