TY - JOUR
T1 - Litoarbolide A
T2 - an undescribed sesquiterpenoid from the Red Sea soft coral Litophyton arboreum with an in vitro anti-malarial activity evaluation
AU - Ahmed, Mohammed M.A.
AU - Ragab, Ehab A.
AU - Zayed, Ahmed
AU - El-Ghaly, Elsayed M.
AU - Ismail, Said K.
AU - Khan, Shabana I.
AU - Ali, Zulfiqar
AU - Chittiboyina, Amar G.
AU - Khan, Ikhlas A.
N1 - Funding Information:
We are grateful to the Egyptian Government represented by the Ministry of Higher Education (MoHE) for the financial support. The authors thank Dr. Avula for acquiring the mass spectral data.
Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral Litophyton arboreum led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide A (1), along with 14 previously reported metabolites (2-15). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data. Litoarbolide A is supposed to be the biosynthetic precursor to other sesquiterpenoids, which formed via further post-translational modifications. Furthermore, these metabolites were evaluated for anti-malarial activity, where only the acyclic sesquiterpenoid of a sec-germacrane nucleus (7) showed an activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 at 3.7 and 2.2 mg/mL, respectively. Moreover, the isolated metabolites were all non-toxic to the Vero cell line. These findings support the consideration of L. arboreum in further natural anti-malarial studies.
AB - Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral Litophyton arboreum led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide A (1), along with 14 previously reported metabolites (2-15). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data. Litoarbolide A is supposed to be the biosynthetic precursor to other sesquiterpenoids, which formed via further post-translational modifications. Furthermore, these metabolites were evaluated for anti-malarial activity, where only the acyclic sesquiterpenoid of a sec-germacrane nucleus (7) showed an activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 at 3.7 and 2.2 mg/mL, respectively. Moreover, the isolated metabolites were all non-toxic to the Vero cell line. These findings support the consideration of L. arboreum in further natural anti-malarial studies.
KW - anti-malarial activity
KW - Litophyton arboreum
KW - sesquiterpenoid
KW - Soft coral
UR - http://www.scopus.com/inward/record.url?scp=85129264491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129264491&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2071268
DO - 10.1080/14786419.2022.2071268
M3 - Article
C2 - 35491702
AN - SCOPUS:85129264491
SN - 1478-6419
JO - Natural Product Research
JF - Natural Product Research
ER -