Lack of effect of chloramphenicol on monoamine, diamine and plasma amine oxidase activities

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Abstract

Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P > 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. Plasma amine oxidase (PAO) was not significantly inhibited (P > 0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). Chloramphenicol (2 x 10-3 mol/l) preincubated with rabbit hepatic MAO had no significant effect (P > 0.1) on the enzyme activity.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume12
Issue number2
Publication statusPublished - 1985

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Diamines
Chloramphenicol
Amines
Oxidoreductases
Monoamine Oxidase
Rabbits
Amine Oxidase (Copper-Containing)
Liver
Goats
Brain
Enzymes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P > 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. Plasma amine oxidase (PAO) was not significantly inhibited (P > 0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). Chloramphenicol (2 x 10-3 mol/l) preincubated with rabbit hepatic MAO had no significant effect (P > 0.1) on the enzyme activity.",
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AB - Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P > 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. Plasma amine oxidase (PAO) was not significantly inhibited (P > 0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). Chloramphenicol (2 x 10-3 mol/l) preincubated with rabbit hepatic MAO had no significant effect (P > 0.1) on the enzyme activity.

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