Interleukin-7 levels may predict virological response in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapy

M. R. Boulassel, G. H.R. Smith, N. Gilmore, M. Klein, T. Murphy, J. MacLeod, R. LeBlanc, J. Allan, P. René, R. G. Lalonde, Jean Pierre Routy

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16 Citations (Scopus)

Abstract

Objectives. To examine the relationship between levels of the T-cell regulatory cytokine interleukin-7 (IL-7) and CD4 cell counts during immune reconstitution and to assess its prognostic value in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapy. Methods. Thirty-six HIV-1-infected adults who completed 48 weeks of follow-up visits were included in this prospective study. Patients having failed two or more antiretroviral therapy regimens were treated with lopinavir/ritonavir-based therapy. An enzyme-linked immunosorbent assay was used to determine IL-7 plasma levels, flow cytometry was used to analyse cell surface antigens, and polymerase chain reaction was used to quantify plasma HIV-1. Results. Pretreatment IL-7 levels were elevated in all patients (mean 11.0 pg/mL) and were negatively correlated with CD4 cell counts and age (r = -0.59, P<0.001 and r = -0.57, P<0.001, respectively). During the course of treatment, IL-7 levels decreased by 34% while CD4 cell numbers progressively increased by 88%. Multivariate regression analysis showed that only pretreatment IL-7 levels predicted viral load at 48 weeks when controlling for baseline CD4 cell counts, viral load and patient demographics. Conclusions. These findings are consistent with regulation of T-cell recovery by IL-7, and suggest that IL-7 measurements might be used to predict virological response.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalHIV Medicine
Volume4
Issue number4
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Antiretroviral therapy
  • HIV
  • Immune reconstitution
  • Interleukin-7
  • Predictive value

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)
  • Infectious Diseases

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    Boulassel, M. R., Smith, G. H. R., Gilmore, N., Klein, M., Murphy, T., MacLeod, J., LeBlanc, R., Allan, J., René, P., Lalonde, R. G., & Routy, J. P. (2003). Interleukin-7 levels may predict virological response in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapy. HIV Medicine, 4(4), 315-320. https://doi.org/10.1046/j.1468-1293.2003.00165.x