Influence of pattern of exposure, parasite genetic diversity and sex on the degree of protection against reinfection with Schistosoma mansoni

M. Dumont, H. Moné, G. Mouahid, M. A. Idris, M. Shaban, J. Boissier

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This paper analyzed, experimentally, the influences of pattern of exposure, parasite genetic diversity, and parasite sex on the degree of protection against reinfection with Schistosoma mansoni in the mouse. The results show that, (1) in infections with one male parasite genotype, successive infections induced a significant decrease in the infectivity of the parasite and significant increases in the spleen and liver weights compared to mass infections, (2) successive infections with one male genotype induced a significant decrease in the infectivity of the parasite compared to successive infections with five male genotypes, and (3) genotype infectivities were determined by the order at which they were used in the successive infections. These results are discussed in terms of protective effect and concomitant immunity and provide an ecological explanation of the natural sex-biased dispersal toward the male schistosomes.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalParasitology Research
Volume101
Issue number2
DOIs
Publication statusPublished - Jul 2007

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Schistosoma mansoni
Parasites
parasites
genetic variation
gender
Infection
Genotype
infection
pathogenicity
genotype
Schistosoma
protective effect
Immunity
spleen
Spleen
immunity
Weights and Measures
liver
Liver
mice

ASJC Scopus subject areas

  • Parasitology

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Influence of pattern of exposure, parasite genetic diversity and sex on the degree of protection against reinfection with Schistosoma mansoni. / Dumont, M.; Moné, H.; Mouahid, G.; Idris, M. A.; Shaban, M.; Boissier, J.

In: Parasitology Research, Vol. 101, No. 2, 07.2007, p. 247-252.

Research output: Contribution to journalArticle

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