Incidence and risk factors of parenteral nutrition-associated cholestasis in omani neonates single centre experience

Sharef W. Sharef, Siham Al-Sinani, Khalid Al-Naamani, Ibrahim Al-Zakwani, Zenaida S. Reyes, Hilal Al-Ryiami, Ashfaq A. Khan, Watfa Al-Mamari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Parenteral nutrition-associated cholestasis (PNAC) is one of the most challenging complications of prolonged parenteral nutrition (PN) in neonates. There is a lack of research investigating its incidence in newborn infants in Oman and the Arab region. Therefore, this study aimed to assess the incidence of PNAC and its risk factors in Omani neonates. Methods: This retrospective study took place between January and April 2014. All neonates who received PN for ≥14 days during a four-year period (June 2009 to May 2013) at the neonatal intensive care unit (NICU) in Sultan Qaboos University Hospital, Muscat, Oman, were enrolled. Results: A total of 1,857 neonates were admitted to the NICU over the study period and 135 neonates (7.3%) received PN for ≥14 days. Determining the incidence of PNAC was only possible in 97 neonates; of these, 38 (39%) had PNAC. The main risk factors associated with PNAC were duration of PN, duration of enteral starvation, gastrointestinal surgeries, blood transfusions and sepsis. Neonates with PNAC had a slightly higher incidence of necrotising enterocolitis in comparison to those without PNAC. Conclusion: This study found a PNAC incidence of 39% in Omani neonates. There were several significant risk factors for PNAC in Omani neonates; however, after logistic regression analysis, only total PN duration remained statistically significant. Preventive strategies should be implemented in NICUs so as to avoid future chronic liver disease in this population.

Original languageEnglish
Pages (from-to)e234-e240
JournalSultan Qaboos University Medical Journal
Volume15
Issue number2
Publication statusPublished - May 1 2015

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Cholestasis
Parenteral Nutrition
Newborn Infant
Incidence
Oman
Neonatal Intensive Care Units
Necrotizing Enterocolitis
Total Parenteral Nutrition
Starvation
Blood Transfusion
Small Intestine
Liver Diseases
Sepsis
Chronic Disease
Retrospective Studies
Logistic Models
Regression Analysis

Keywords

  • Cholestasis
  • Incidence
  • Neonates
  • Oman
  • Parenteral nutrition
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence and risk factors of parenteral nutrition-associated cholestasis in omani neonates single centre experience. / Sharef, Sharef W.; Al-Sinani, Siham; Al-Naamani, Khalid; Al-Zakwani, Ibrahim; Reyes, Zenaida S.; Al-Ryiami, Hilal; Khan, Ashfaq A.; Al-Mamari, Watfa.

In: Sultan Qaboos University Medical Journal, Vol. 15, No. 2, 01.05.2015, p. e234-e240.

Research output: Contribution to journalArticle

Sharef, Sharef W. ; Al-Sinani, Siham ; Al-Naamani, Khalid ; Al-Zakwani, Ibrahim ; Reyes, Zenaida S. ; Al-Ryiami, Hilal ; Khan, Ashfaq A. ; Al-Mamari, Watfa. / Incidence and risk factors of parenteral nutrition-associated cholestasis in omani neonates single centre experience. In: Sultan Qaboos University Medical Journal. 2015 ; Vol. 15, No. 2. pp. e234-e240.
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AU - Al-Sinani, Siham

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AU - Al-Zakwani, Ibrahim

AU - Reyes, Zenaida S.

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AU - Khan, Ashfaq A.

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