Incidence and pattern of thyroid dysfunction in patients on chronic amiodarone therapy: Experience at a tertiary care centre in Oman

H. Farhan, A. Albulushi, A. Taqi, A. Al-Hashim, K. Al-Saidi, K. Al-Rasadi, A. Al-Mazroui, I. Al-Zakwani

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3 Citations (Scopus)

Abstract

Objective: To determine the incidence and pattern of thyroid dysfunction (TD) in patients on chronic amiodarone therapy. Methods: A retrospective study which evaluated 59 patients who had received amiodarone therapy regularly for at least 12 months from a period of 3 years from October 2007 to October 2010. The patients were followed-up at the cardiac clinic at Sultan Qaboos University Hospital, Muscat, Oman. Results: The mean age of the cohort was 63 ± 13 years ranging from 27 to 98 years. Fifty-one percent (n = 30) of the pa-tients were female. There were 11 (19%) cases of thyroid dysfunction (TD). Seven (12%) patients were hypothyroid, 3 (5%) had hyperthyroidism and 1 (2%) patient had sub-clinical hypothyroidism; no cases of sub-clinical hyperthyroidism were noted. Female gender and presence of anti-thyroid peroxidase antibodies were significantly associated with amiodarone-induced hypothyroidism (p = 0.001) while age, amiodarone dose and duration of therapy were not correlated with the development of TD (all p-values > 0.05). Conclusion: Amiodarone-induced thyroid dysfunction is prevalent. Hypothyroidism was more frequent and seen more in female patients and those who had positive anti-thyroid peroxidase antibodies. Initial screening and periodic monitoring of thyroid function is mandatory for all patients on amiodarone therapy.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalOpen Cardiovascular Medicine Journal
Volume7
Issue number1
DOIs
Publication statusPublished - 2013

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Keywords

  • Amiodarone
  • Hyperthyroidism
  • Hypothyroidism
  • Oman
  • Thyroid diseases
  • Thyrotoxicosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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