Inbuilt Tendency of the eIF2 Regulatory System to Counteract Uncertainties

Mohammad Farhan Khan*, Sarah K. Spurgeon, Xing Gang Yan, Muaffaq M. Nofal, Rami Al-Hmouz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the regulation of eIF2 is robust against intrinsic uncertainties and is able to efficiently counteract them. The robustness properties of the eIF2 pathway against intrinsic disturbances is also well known. However the reasons for this ability to counteract stresses is less well understood. In this article, the robustness conferring properties of the eIF2 dependent regulatory system is explored with the help of a mathematical model. The novelty of the work presented in this article lies in articulating the possible reason behind the inbuilt robustness of the highly engineered eIF2 system against intrinsic perturbations. Our investigations reveal that the robust nature of the eIF2 pathway may originate from the existence of an attractive natural sliding surface within the system satisfying reaching and sliding conditions that are well established in the domain of control engineering.

Original languageEnglish
Article number9187638
Pages (from-to)35-41
Number of pages7
JournalIEEE Transactions on Nanobioscience
Issue number1
Publication statusPublished - Jan 2021


  • key non-linearities
  • linearisation
  • mathematical modelling
  • Protein synthesis
  • sliding surface
  • stability

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering


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