Impaired antioxidant status and reduced energy metabolism in autistic children

M. M. Essa, N. Braidy, M. I. Waly, Y. M. Al-Farsi, M. Al-Sharbati, S. Subash, A. Amanat, M. A. Al-Shaffaee, G. J. Guillemin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Accumulating evidence suggests that oxidative stress induced mechanisms are believed to be associated with the pathophysiology of autism. In this study, we recruited 19 Omani autistic children with age-matched controls to analyze their plasma and serum redox status and the levels of ATP, NAD+ and NADH using well established spectrophotometric assays. A significant decrease was observed in the levels of plasma total antioxidants (TA), reduced glutathione (GSH), superoxide and catalase activity in Omani autistic children as compared to their age-matched controls. In contrary, the level of plasma glutathione peroxidase (GSH-Px) was significantly increased in autistic children. Reduced serum NAD+ and ATP levels and lower NAD+:NADH ratio were observedin patients with autism compared to controls. Finally, a significant inverse correlation was observed between plasma GSH, SOD, catalase activity, and serum NAD+ and ATP levels, and autism severity using Childhood Autism Rating Scale (CARS) scores. The levels of plasma GSH-Px and serum NADH correlated strongly with autism severity whilst no significant correlation was observed for plasma TA. Our data suggests that increased vulnerability to oxidative stress in autism may occur as a consequence of alterations in antioxidant enzymes leading to mitochondrial dysfunction.

Original languageEnglish
Pages (from-to)557-565
Number of pages9
JournalResearch in Autism Spectrum Disorders
Volume7
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

NAD
Energy Metabolism
Autistic Disorder
Antioxidants
Adenosine Triphosphate
Serum
Catalase
Oxidative Stress
Glutathione Peroxidase
Superoxides
Oxidation-Reduction
Glutathione
Enzymes

Keywords

  • Antioxidants
  • ATP
  • Autism
  • NAD
  • Oxidative stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Impaired antioxidant status and reduced energy metabolism in autistic children. / Essa, M. M.; Braidy, N.; Waly, M. I.; Al-Farsi, Y. M.; Al-Sharbati, M.; Subash, S.; Amanat, A.; Al-Shaffaee, M. A.; Guillemin, G. J.

In: Research in Autism Spectrum Disorders, Vol. 7, No. 5, 2013, p. 557-565.

Research output: Contribution to journalArticle

Essa, M. M. ; Braidy, N. ; Waly, M. I. ; Al-Farsi, Y. M. ; Al-Sharbati, M. ; Subash, S. ; Amanat, A. ; Al-Shaffaee, M. A. ; Guillemin, G. J. / Impaired antioxidant status and reduced energy metabolism in autistic children. In: Research in Autism Spectrum Disorders. 2013 ; Vol. 7, No. 5. pp. 557-565.
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