Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study

Ibrahim Al-Zakwani, Wael Al Mahmeed, Abdullah Shehab, Mohamed Arafah, Ali T. Al-Hinai, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar Ahmed S Baslaib, Haitham AminKhalid Al-Waili, Khamis Al-Hashmi, Raul D. Santos, Khalid Al-Rasadi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P <0.001), LDL-C (27 vs. 37 %; P <0.001), non HDL-C (35 vs. 55 %; P <0.001) and Apo B (35 vs. 54 %; P <0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P <0.001), LDL-C (24 vs. 43 %; P <0.001), non HDL-C (32 vs. 51 %; P <0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P <0.001), LDL-C (19 vs. 27 %; P <0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

Original languageEnglish
Article number49
JournalDiabetology and Metabolic Syndrome
Volume8
Issue number1
DOIs
Publication statusPublished - Jul 26 2016

Keywords

  • Arabian Gulf
  • Blood pressure
  • Cardiovascular diseases
  • HDL cholesterol
  • LDL cholesterol
  • Metabolic syndrome
  • Obesity
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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