Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study

Ibrahim Al-Zakwani, Wael Al Mahmeed, Abdullah Shehab, Mohamed Arafah, Ali T. Al-Hinai, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar Ahmed S Baslaib, Haitham AminKhalid Al-Waili, Khamis Al-Hashmi, Raul D. Santos, Khalid Al-Rasadi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P <0.001), LDL-C (27 vs. 37 %; P <0.001), non HDL-C (35 vs. 55 %; P <0.001) and Apo B (35 vs. 54 %; P <0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P <0.001), LDL-C (24 vs. 43 %; P <0.001), non HDL-C (32 vs. 51 %; P <0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P <0.001), LDL-C (19 vs. 27 %; P <0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

Original languageEnglish
Article number49
JournalDiabetology and Metabolic Syndrome
Volume8
Issue number1
DOIs
Publication statusPublished - Jul 26 2016

Fingerprint

Lipids
Cardiovascular Diseases
Apolipoproteins B
Middle East
Hypercholesterolemia
oxidized low density lipoprotein
C 27
Therapeutics

Keywords

  • Arabian Gulf
  • Blood pressure
  • Cardiovascular diseases
  • HDL cholesterol
  • LDL cholesterol
  • Metabolic syndrome
  • Obesity
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf : Findings from the CEPHEUS study. / Al-Zakwani, Ibrahim; Al Mahmeed, Wael; Shehab, Abdullah; Arafah, Mohamed; Al-Hinai, Ali T.; Al Tamimi, Omer; Al Awadhi, Mahmoud; Al Herz, Shorook; Al Anazi, Faisal; Al Nemer, Khalid; Metwally, Othman; Alkhadra, Akram; Fakhry, Mohammed; Elghetany, Hossam; Medani, Abdel Razak; Yusufali, Afzal Hussein; Al Jassim, Obaid; Al Hallaq, Omar; Baslaib, Fahad Omar Ahmed S; Amin, Haitham; Al-Waili, Khalid; Al-Hashmi, Khamis; Santos, Raul D.; Al-Rasadi, Khalid.

In: Diabetology and Metabolic Syndrome, Vol. 8, No. 1, 49, 26.07.2016.

Research output: Contribution to journalArticle

Al-Zakwani, I, Al Mahmeed, W, Shehab, A, Arafah, M, Al-Hinai, AT, Al Tamimi, O, Al Awadhi, M, Al Herz, S, Al Anazi, F, Al Nemer, K, Metwally, O, Alkhadra, A, Fakhry, M, Elghetany, H, Medani, AR, Yusufali, AH, Al Jassim, O, Al Hallaq, O, Baslaib, FOAS, Amin, H, Al-Waili, K, Al-Hashmi, K, Santos, RD & Al-Rasadi, K 2016, 'Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study', Diabetology and Metabolic Syndrome, vol. 8, no. 1, 49. https://doi.org/10.1186/s13098-016-0160-6
Al-Zakwani, Ibrahim ; Al Mahmeed, Wael ; Shehab, Abdullah ; Arafah, Mohamed ; Al-Hinai, Ali T. ; Al Tamimi, Omer ; Al Awadhi, Mahmoud ; Al Herz, Shorook ; Al Anazi, Faisal ; Al Nemer, Khalid ; Metwally, Othman ; Alkhadra, Akram ; Fakhry, Mohammed ; Elghetany, Hossam ; Medani, Abdel Razak ; Yusufali, Afzal Hussein ; Al Jassim, Obaid ; Al Hallaq, Omar ; Baslaib, Fahad Omar Ahmed S ; Amin, Haitham ; Al-Waili, Khalid ; Al-Hashmi, Khamis ; Santos, Raul D. ; Al-Rasadi, Khalid. / Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf : Findings from the CEPHEUS study. In: Diabetology and Metabolic Syndrome. 2016 ; Vol. 8, No. 1.
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abstract = "Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 {\%} were females and 71 {\%} had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 {\%}; P <0.001), LDL-C (27 vs. 37 {\%}; P <0.001), non HDL-C (35 vs. 55 {\%}; P <0.001) and Apo B (35 vs. 54 {\%}; P <0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 {\%}; P <0.001), LDL-C (24 vs. 43 {\%}; P <0.001), non HDL-C (32 vs. 51 {\%}; P <0.001) and Apo B (33 vs. 40 {\%}; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 {\%}; P <0.001), LDL-C (19 vs. 27 {\%}; P <0.001) and Apo B (30 vs. 35 {\%}; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.",
keywords = "Arabian Gulf, Blood pressure, Cardiovascular diseases, HDL cholesterol, LDL cholesterol, Metabolic syndrome, Obesity, Triglycerides",
author = "Ibrahim Al-Zakwani and {Al Mahmeed}, Wael and Abdullah Shehab and Mohamed Arafah and Al-Hinai, {Ali T.} and {Al Tamimi}, Omer and {Al Awadhi}, Mahmoud and {Al Herz}, Shorook and {Al Anazi}, Faisal and {Al Nemer}, Khalid and Othman Metwally and Akram Alkhadra and Mohammed Fakhry and Hossam Elghetany and Medani, {Abdel Razak} and Yusufali, {Afzal Hussein} and {Al Jassim}, Obaid and {Al Hallaq}, Omar and Baslaib, {Fahad Omar Ahmed S} and Haitham Amin and Khalid Al-Waili and Khamis Al-Hashmi and Santos, {Raul D.} and Khalid Al-Rasadi",
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T1 - Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf

T2 - Findings from the CEPHEUS study

AU - Al-Zakwani, Ibrahim

AU - Al Mahmeed, Wael

AU - Shehab, Abdullah

AU - Arafah, Mohamed

AU - Al-Hinai, Ali T.

AU - Al Tamimi, Omer

AU - Al Awadhi, Mahmoud

AU - Al Herz, Shorook

AU - Al Anazi, Faisal

AU - Al Nemer, Khalid

AU - Metwally, Othman

AU - Alkhadra, Akram

AU - Fakhry, Mohammed

AU - Elghetany, Hossam

AU - Medani, Abdel Razak

AU - Yusufali, Afzal Hussein

AU - Al Jassim, Obaid

AU - Al Hallaq, Omar

AU - Baslaib, Fahad Omar Ahmed S

AU - Amin, Haitham

AU - Al-Waili, Khalid

AU - Al-Hashmi, Khamis

AU - Santos, Raul D.

AU - Al-Rasadi, Khalid

PY - 2016/7/26

Y1 - 2016/7/26

N2 - Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P <0.001), LDL-C (27 vs. 37 %; P <0.001), non HDL-C (35 vs. 55 %; P <0.001) and Apo B (35 vs. 54 %; P <0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P <0.001), LDL-C (24 vs. 43 %; P <0.001), non HDL-C (32 vs. 51 %; P <0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P <0.001), LDL-C (19 vs. 27 %; P <0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

AB - Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P <0.001), LDL-C (27 vs. 37 %; P <0.001), non HDL-C (35 vs. 55 %; P <0.001) and Apo B (35 vs. 54 %; P <0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P <0.001), LDL-C (24 vs. 43 %; P <0.001), non HDL-C (32 vs. 51 %; P <0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P <0.001), LDL-C (19 vs. 27 %; P <0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

KW - Arabian Gulf

KW - Blood pressure

KW - Cardiovascular diseases

KW - HDL cholesterol

KW - LDL cholesterol

KW - Metabolic syndrome

KW - Obesity

KW - Triglycerides

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