Immunizing effects of live Corynebacterium pseudotuberculosis in goats

E. H. Johnson, J. Santa Rosa, P. H. Kass

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Twenty goats ranging from 4 to 7 months of age were divided into two groups. Group 1 consisted of five goats inoculated intradermally with 4.0 × 106 virulent Corynebacterium pseudotuberculosis. Group 2 consisted of fifteen goats vaccinated intradermally with a single dose of 20 × 103 C. pseudotuberculosis. Twelve weeks later the goats in group 2 were reinoculated with 4.0 × 106 virulent organisms. All goats from group 1 developed abscesses at the site of inoculation, in the draining lymph nodes, as well as in internal viscera and or lymph nodes. None of the goats in group 2 developed abscesses in their external lymph nodes or viscera but one goat had a small abscess in a single mesenteric lymph node and one goat in a retropharyngeal lymph node. Ten of the 15 goats from group 2 had small abscesses at the site of inoculation which developed after the challenge inoculation. It was concluded that small doses of live C. pseudotuberculosis stimulated an immune response capable of preventing the development of abscesses in the draining lymph node as well as protected against the development of internal abscesses.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalSmall Ruminant Research
Volume12
Issue number3
DOIs
Publication statusPublished - 1993

Fingerprint

Corynebacterium pseudotuberculosis
Goats
goats
abscess
Abscess
lymph nodes
Lymph Nodes
Viscera
animal organs
dosage
immune response

Keywords

  • Abscess
  • C. pseudotuberculosis
  • Caseous lymphadenitis
  • Goat
  • Immunization

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Immunizing effects of live Corynebacterium pseudotuberculosis in goats. / Johnson, E. H.; Santa Rosa, J.; Kass, P. H.

In: Small Ruminant Research, Vol. 12, No. 3, 1993, p. 349-356.

Research output: Contribution to journalArticle

Johnson, E. H. ; Santa Rosa, J. ; Kass, P. H. / Immunizing effects of live Corynebacterium pseudotuberculosis in goats. In: Small Ruminant Research. 1993 ; Vol. 12, No. 3. pp. 349-356.
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