Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis

Jayakrishnan Nair, Saif M. Al-Mubaihsi, Masoud S. Kashoub, Jojy George

Research output: Contribution to journalArticle

Abstract

The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. These findings, in addition to the presence of calciuria and a high angiotensin-converting enzyme (ACE) level, confirmed a clinical diagnosis of sarcoidosis. The patient responded well to treatment with oral prednisolone which, over the course of two years, resulted in the near-complete resolution of parenchymal nodular infiltrates, regression of hilar lymphadenopathy, resolution of hypercalcaemia and the normalisation of his ACE levels. Diagnosing pulmonary sarcoidosis in CF can be challenging as most adult patients already have extensive lung disease. Physicians should be aware that hypercalcaemia may be an early manifestation of sarcoidosis in such cases.

Original languageEnglish
Pages (from-to)e533-e536
JournalSultan Qaboos University Medical Journal
Volume18
Issue number4
DOIs
Publication statusPublished - Nov 1 2018

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Hypercalcemia
Sarcoidosis
Cystic Fibrosis
Peptidyl-Dipeptidase A
Oman
Pulmonary Sarcoidosis
Anterior Uveitis
Prednisolone
Lung Diseases
Tomography
Physicians
Lymphadenopathy
Therapeutics

Keywords

  • Case Report
  • Cystic Fibrosis
  • Hypercalcemia
  • Oman
  • Sarcoidosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypercalcaemia : A portent of sarcoidosis in cystic fibrosis. / Nair, Jayakrishnan; Al-Mubaihsi, Saif M.; Kashoub, Masoud S.; George, Jojy.

In: Sultan Qaboos University Medical Journal, Vol. 18, No. 4, 01.11.2018, p. e533-e536.

Research output: Contribution to journalArticle

Nair, Jayakrishnan ; Al-Mubaihsi, Saif M. ; Kashoub, Masoud S. ; George, Jojy. / Hypercalcaemia : A portent of sarcoidosis in cystic fibrosis. In: Sultan Qaboos University Medical Journal. 2018 ; Vol. 18, No. 4. pp. e533-e536.
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