High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study

Raid J. Abdel-Jalil*, Monther Khanfar, Samer Al-Gharabli, Mustafa M. El-Abadelah, Klaus Eichele, Muhammad Usman Anwar, Wolfgang Voelter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A rapid and easy high-yielding synthesis of pyrazolopyrimidinones in the presensce of copper chloride is described. To fully confirm the structure of a Viagra® intermediate, the X-Ray structure of 5-(2-ethoxyphenyl)-1-methyl-3- propyl-1,6-dihydropyrazolo[4,3-d]pyrimidin-7-one (2a) was determined.

Original languageEnglish
Pages (from-to)1821-1827
Number of pages7
JournalHeterocycles
Volume65
Issue number8
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Organic Chemistry

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