High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study

Raid J. Abdel-Jalil, Monther Khanfar, Samer Al-Gharabli, Mustafa M. El-Abadelah, Klaus Eichele, Muhammad Usman Anwar, Wolfgang Voelter

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Abstract

A rapid and easy high-yielding synthesis of pyrazolopyrimidinones in the presensce of copper chloride is described. To fully confirm the structure of a Viagra® intermediate, the X-Ray structure of 5-(2-ethoxyphenyl)-1-methyl-3- propyl-1,6-dihydropyrazolo[4,3-d]pyrimidin-7-one (2a) was determined.

Original languageEnglish
Pages (from-to)1821-1827
Number of pages7
JournalHeterocycles
Volume65
Issue number8
DOIs
Publication statusPublished - 2005

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Abdel-Jalil, R. J., Khanfar, M., Al-Gharabli, S., El-Abadelah, M. M., Eichele, K., Anwar, M. U., & Voelter, W. (2005). High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study. Heterocycles, 65(8), 1821-1827. https://doi.org/10.3987/COM-05-10398