High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study

Raid J. Abdel-Jalil, Monther Khanfar, Samer Al-Gharabli, Mustafa M. El-Abadelah, Klaus Eichele, Muhammad Usman Anwar, Wolfgang Voelter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A rapid and easy high-yielding synthesis of pyrazolopyrimidinones in the presensce of copper chloride is described. To fully confirm the structure of a Viagra® intermediate, the X-Ray structure of 5-(2-ethoxyphenyl)-1-methyl-3- propyl-1,6-dihydropyrazolo[4,3-d]pyrimidin-7-one (2a) was determined.

Original languageEnglish
Pages (from-to)1821-1827
Number of pages7
JournalHeterocycles
Volume65
Issue number8
DOIs
Publication statusPublished - 2005

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Cyclization
Chlorides
Copper
Throughput
X-Rays
X rays
Sildenafil Citrate

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Abdel-Jalil, R. J., Khanfar, M., Al-Gharabli, S., El-Abadelah, M. M., Eichele, K., Anwar, M. U., & Voelter, W. (2005). High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study. Heterocycles, 65(8), 1821-1827. https://doi.org/10.3987/COM-05-10398

High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study. / Abdel-Jalil, Raid J.; Khanfar, Monther; Al-Gharabli, Samer; El-Abadelah, Mustafa M.; Eichele, Klaus; Anwar, Muhammad Usman; Voelter, Wolfgang.

In: Heterocycles, Vol. 65, No. 8, 2005, p. 1821-1827.

Research output: Contribution to journalArticle

Abdel-Jalil, RJ, Khanfar, M, Al-Gharabli, S, El-Abadelah, MM, Eichele, K, Anwar, MU & Voelter, W 2005, 'High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study', Heterocycles, vol. 65, no. 8, pp. 1821-1827. https://doi.org/10.3987/COM-05-10398
Abdel-Jalil, Raid J. ; Khanfar, Monther ; Al-Gharabli, Samer ; El-Abadelah, Mustafa M. ; Eichele, Klaus ; Anwar, Muhammad Usman ; Voelter, Wolfgang. / High throughput synthesis of pyrazolopyrimidines via copper- catalysed cyclization and X-ray study. In: Heterocycles. 2005 ; Vol. 65, No. 8. pp. 1821-1827.
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