Hidden focal EEG seizures during prolonged suppressions and high-amplitude bursts in early infantile epileptic encephalopathy

Amna Al-Futaisi, Brenda Banwell, Ayako Ochi, Justine Hew, Bill Chu, Makoto Oishi, Hiroshi Otsubo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: We report on a 27-month-old female with atypical early infantile epileptic encephalopathy (EIEE), who developed tonic spasms, partial seizures and myoclonic jerks along with episodic bradycardia at 5 days. Methods: We recorded digital electroencephalography (EEG) using either an 11-channel neonatal montage or 19 channel scalp electrodes, at 200 Hz sampling rate, and a single reference for a minimum of 30 min. Results: At 18 days EEG showed suppression-burst (SB) patterns during wakefulness and sleep. Tonic spasms concomitant with bursts recorded as brief, low-amplitude fast waves. EEG at 8 months showed increased amplitude of bursts to 1 mV and extension of suppression periods to 65 s. By increasing recording sensitivity, we detected focal epileptiform discharges of slow rhythmic sharp and slow waves building to 30 μV during suppression periods. Status epilepticus occurred at 16 months. EEG at 27 months returned to the previous SB pattern with rare partial seizures. Conclusions: This report is the first to demonstrate clinically silent focal EEG seizures during prolonged suppression periods in atypical EIEE by off-line digital EEG. Significance: Digital EEG sensitivity can reveal covert electrical activity during suppression periods in epileptic neonates and infants.

Original languageEnglish
Pages (from-to)1113-1117
Number of pages5
JournalClinical Neurophysiology
Volume116
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords

  • Digital EEG
  • Early infantile epileptic encephalopathy
  • Hidden focal EEG seizure
  • Interictal discharge
  • Suppression-burst pattern

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems

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