Heritability of determinants of the metabolic syndrome among healthy Arabs of the Oman family study

Riad A. Bayoumi, Saeed A S Al-Yahyaee, Sulayma A. Albarwani, Syed G. Rizvi, Saleh Al-Hadabi, Firial F. Al-Ubaidi, Ali T. Al-Hinai, Mohammed N. Al-Kindi, Haleema T. Adnan, Hameeda S. Al-Barwany, Antony G. Comuzzie, Cai Guowen, Juan C. Lopez-Alvarenga, Mohammed O. Hassan

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52 Citations (Scopus)

Abstract

The metabolic syndrome, as defined by the International Diabetes Federation, was investigated in five large, extended, highly consanguineous, healthy Omani Arab families of a total of 1277 individuals. Heritability (h 2) of the phenotypic abnormalities that make up the syndrome and other related traits was estimated by variance decomposition method using SOLAR software. The overall prevalence of the syndrome was 23%. The prevalence of abnormalities making the syndrome in a descending order were: obligatory waist circumference, hypertension, raised fasting blood glucose, low serum high-density lipoprotein (HDL), and raised serum triglycerides (TGs). Highly significant, but widely spread, h2 values were obtained for: height (0.68), weight (0.68), BMI (0.68), serum HDL (0.63), serum leptin (0.55), percentage body fat (0.53), total serum cholesterol (0.53), fasting serum insulin (0.51), homeostasis model assessment-insulin resistance index (0.48), serum TG (0.43), waist circumference (0.40), diastolic blood pressure (0.38), and 2-hour glucose level (0.17), whereas for the metabolic syndrome itself, h2 was 0.38. The wide spread of h2 results (0.07 to 0.68) indicates that some determinants, such as weight, BMI, and HDL level, are under significant genetic influence among the Omani Arabs. Other determinants such as insulin resistance, abdominal obesity, diastolic blood pressure, and TG levels seem to be more environmentally driven.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalObesity
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Ethnic groups
  • Family studies
  • Genetics
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Bayoumi, R. A., Al-Yahyaee, S. A. S., Albarwani, S. A., Rizvi, S. G., Al-Hadabi, S., Al-Ubaidi, F. F., Al-Hinai, A. T., Al-Kindi, M. N., Adnan, H. T., Al-Barwany, H. S., Comuzzie, A. G., Guowen, C., Lopez-Alvarenga, J. C., & Hassan, M. O. (2007). Heritability of determinants of the metabolic syndrome among healthy Arabs of the Oman family study. Obesity, 15(3), 551-556. https://doi.org/10.1038/oby.2007.555