TY - JOUR
T1 - Heritability of determinants of the metabolic syndrome among healthy Arabs of the Oman family study
AU - Bayoumi, Riad A.
AU - Al-Yahyaee, Saeed A.S.
AU - Albarwani, Sulayma A.
AU - Rizvi, Syed G.
AU - Al-Hadabi, Saleh
AU - Al-Ubaidi, Firial F.
AU - Al-Hinai, Ali T.
AU - Al-Kindi, Mohammed N.
AU - Adnan, Haleema T.
AU - Al-Barwany, Hameeda S.
AU - Comuzzie, Antony G.
AU - Guowen, Cai
AU - Lopez-Alvarenga, Juan C.
AU - Hassan, Mohammed O.
PY - 2007/3
Y1 - 2007/3
N2 - The metabolic syndrome, as defined by the International Diabetes Federation, was investigated in five large, extended, highly consanguineous, healthy Omani Arab families of a total of 1277 individuals. Heritability (h 2) of the phenotypic abnormalities that make up the syndrome and other related traits was estimated by variance decomposition method using SOLAR software. The overall prevalence of the syndrome was 23%. The prevalence of abnormalities making the syndrome in a descending order were: obligatory waist circumference, hypertension, raised fasting blood glucose, low serum high-density lipoprotein (HDL), and raised serum triglycerides (TGs). Highly significant, but widely spread, h2 values were obtained for: height (0.68), weight (0.68), BMI (0.68), serum HDL (0.63), serum leptin (0.55), percentage body fat (0.53), total serum cholesterol (0.53), fasting serum insulin (0.51), homeostasis model assessment-insulin resistance index (0.48), serum TG (0.43), waist circumference (0.40), diastolic blood pressure (0.38), and 2-hour glucose level (0.17), whereas for the metabolic syndrome itself, h2 was 0.38. The wide spread of h2 results (0.07 to 0.68) indicates that some determinants, such as weight, BMI, and HDL level, are under significant genetic influence among the Omani Arabs. Other determinants such as insulin resistance, abdominal obesity, diastolic blood pressure, and TG levels seem to be more environmentally driven.
AB - The metabolic syndrome, as defined by the International Diabetes Federation, was investigated in five large, extended, highly consanguineous, healthy Omani Arab families of a total of 1277 individuals. Heritability (h 2) of the phenotypic abnormalities that make up the syndrome and other related traits was estimated by variance decomposition method using SOLAR software. The overall prevalence of the syndrome was 23%. The prevalence of abnormalities making the syndrome in a descending order were: obligatory waist circumference, hypertension, raised fasting blood glucose, low serum high-density lipoprotein (HDL), and raised serum triglycerides (TGs). Highly significant, but widely spread, h2 values were obtained for: height (0.68), weight (0.68), BMI (0.68), serum HDL (0.63), serum leptin (0.55), percentage body fat (0.53), total serum cholesterol (0.53), fasting serum insulin (0.51), homeostasis model assessment-insulin resistance index (0.48), serum TG (0.43), waist circumference (0.40), diastolic blood pressure (0.38), and 2-hour glucose level (0.17), whereas for the metabolic syndrome itself, h2 was 0.38. The wide spread of h2 results (0.07 to 0.68) indicates that some determinants, such as weight, BMI, and HDL level, are under significant genetic influence among the Omani Arabs. Other determinants such as insulin resistance, abdominal obesity, diastolic blood pressure, and TG levels seem to be more environmentally driven.
KW - Ethnic groups
KW - Family studies
KW - Genetics
KW - Metabolic syndrome
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U2 - 10.1038/oby.2007.555
DO - 10.1038/oby.2007.555
M3 - Article
C2 - 17372303
AN - SCOPUS:34247358692
SN - 1930-7381
VL - 15
SP - 551
EP - 556
JO - Obesity
JF - Obesity
IS - 3
ER -
