Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees

The 'oman family study'

Sulayma Albarwani, M. Loretto Muñoz, V. Saroja Voruganti, Deepali Jaju, V. Saeed Al-Yahyaee, Syed G. Rizvi, Juan C. Lopez-Alvarenga, Zahir M. Al-Anqoudi, Riad A. Bayoumi, Anthony G. Comuzzie, Harold Snieder, Mohammed O. Hassan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20, respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods, which were estimated within a narrow range of 0.18-0.21. Conclusion: In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.

Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalTwin Research and Human Genetics
Volume15
Issue number6
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Oman
Pedigree
Blood Pressure
Heart Rate
Sleep
Blood Pressure Monitors
Advisory Committees
Software

Keywords

  • ambulatory blood pressure
  • beat-to-beat blood pressure
  • heritability
  • Omani pedigrees

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees : The 'oman family study'. / Albarwani, Sulayma; Muñoz, M. Loretto; Voruganti, V. Saroja; Jaju, Deepali; Al-Yahyaee, V. Saeed; Rizvi, Syed G.; Lopez-Alvarenga, Juan C.; Al-Anqoudi, Zahir M.; Bayoumi, Riad A.; Comuzzie, Anthony G.; Snieder, Harold; Hassan, Mohammed O.

In: Twin Research and Human Genetics, Vol. 15, No. 6, 12.2012, p. 753-758.

Research output: Contribution to journalArticle

Albarwani, S, Muñoz, ML, Voruganti, VS, Jaju, D, Al-Yahyaee, VS, Rizvi, SG, Lopez-Alvarenga, JC, Al-Anqoudi, ZM, Bayoumi, RA, Comuzzie, AG, Snieder, H & Hassan, MO 2012, 'Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees: The 'oman family study'', Twin Research and Human Genetics, vol. 15, no. 6, pp. 753-758. https://doi.org/10.1017/thg.2012.59
Albarwani, Sulayma ; Muñoz, M. Loretto ; Voruganti, V. Saroja ; Jaju, Deepali ; Al-Yahyaee, V. Saeed ; Rizvi, Syed G. ; Lopez-Alvarenga, Juan C. ; Al-Anqoudi, Zahir M. ; Bayoumi, Riad A. ; Comuzzie, Anthony G. ; Snieder, Harold ; Hassan, Mohammed O. / Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees : The 'oman family study'. In: Twin Research and Human Genetics. 2012 ; Vol. 15, No. 6. pp. 753-758.
@article{f86bf0c39f3144dd92fcdc75d1778812,
title = "Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees: The 'oman family study'",
abstract = "Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20, respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods, which were estimated within a narrow range of 0.18-0.21. Conclusion: In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.",
keywords = "ambulatory blood pressure, beat-to-beat blood pressure, heritability, Omani pedigrees",
author = "Sulayma Albarwani and Mu{\~n}oz, {M. Loretto} and Voruganti, {V. Saroja} and Deepali Jaju and Al-Yahyaee, {V. Saeed} and Rizvi, {Syed G.} and Lopez-Alvarenga, {Juan C.} and Al-Anqoudi, {Zahir M.} and Bayoumi, {Riad A.} and Comuzzie, {Anthony G.} and Harold Snieder and Hassan, {Mohammed O.}",
year = "2012",
month = "12",
doi = "10.1017/thg.2012.59",
language = "English",
volume = "15",
pages = "753--758",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",
number = "6",

}

TY - JOUR

T1 - Heritability of ambulatory and beat-to-beat office blood pressure in large multigenerational arab pedigrees

T2 - The 'oman family study'

AU - Albarwani, Sulayma

AU - Muñoz, M. Loretto

AU - Voruganti, V. Saroja

AU - Jaju, Deepali

AU - Al-Yahyaee, V. Saeed

AU - Rizvi, Syed G.

AU - Lopez-Alvarenga, Juan C.

AU - Al-Anqoudi, Zahir M.

AU - Bayoumi, Riad A.

AU - Comuzzie, Anthony G.

AU - Snieder, Harold

AU - Hassan, Mohammed O.

PY - 2012/12

Y1 - 2012/12

N2 - Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20, respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods, which were estimated within a narrow range of 0.18-0.21. Conclusion: In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.

AB - Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20, respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods, which were estimated within a narrow range of 0.18-0.21. Conclusion: In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.

KW - ambulatory blood pressure

KW - beat-to-beat blood pressure

KW - heritability

KW - Omani pedigrees

UR - http://www.scopus.com/inward/record.url?scp=84873365845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873365845&partnerID=8YFLogxK

U2 - 10.1017/thg.2012.59

DO - 10.1017/thg.2012.59

M3 - Article

VL - 15

SP - 753

EP - 758

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 6

ER -