Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep

Abulgasim Ahbara, Hussain Bahbahani, Faisal Almathen, Mohammed Al-Abri, Mukhtar Omar Agoub, Ayelle Abeba, Adebabay Kebede, Hassan Hussein Musa, Salvatore Mastrangelo, Fabio Pilla, Elena Ciani, Olivier Hanotte, Joram M. Mwacharo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Variations in body weight and in the distribution of body fat are associated with feed availability, thermoregulation, and energy reserve. Ethiopia is characterized by distinct agro-ecological and human ethnic farmer diversity of ancient origin, which have impacted on the variation of its indigenous livestock. Here, we investigate autosomal genome-wide profiles of 11 Ethiopian indigenous sheep populations using the Illumina Ovine 50 K SNP BeadChip assay. Sheep from the Caribbean, Europe, Middle East, China, and western, northern and southern Africa were included to address globally, the genetic variation and history of Ethiopian populations. Population relationship and structure analysis separated Ethiopian indigenous fat-tail sheep from their North African and Middle Eastern counterparts. It indicates two main genetic backgrounds and supports two distinct genetic histories for African fat-tail sheep. Within Ethiopian sheep, our results show that the short fat-tail sheep do not represent a monophyletic group. Four genetic backgrounds are present in Ethiopian indigenous sheep but at different proportions among the fat-rump and the long fat-tail sheep from western and southern Ethiopia. The Ethiopian fat-rump sheep share a genetic background with Sudanese thin-tail sheep. Genome-wide selection signature analysis identified eight putative candidate regions spanning genes influencing growth traits and fat deposition (NPR2, HINT2, SPAG8, INSR), development of limbs and skeleton, and tail formation (ALX4, HOXB13, BMP4), embryonic development of tendons, bones and cartilages (EYA2, SULF2), regulation of body temperature (TRPM8), body weight and height variation (DIS3L2), control of lipogenesis and intracellular transport of long-chain fatty acids (FABP3), the occurrence and morphology of horns (RXFP2), and response to heat stress (DNAJC18). Our findings suggest that Ethiopian fat-tail sheep represent a uniquely admixed but distinct genepool that presents an important resource for understanding the genetic control of skeletal growth, fat metabolism and associated physiological processes.

Original languageEnglish
JournalFrontiers in Genetics
Volume10
Issue numberJAN
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Tail
Sheep
Fats
Genome
Genes
Ethiopia
Body Temperature Regulation
Body Weight
Physiological Phenomena
Body Fat Distribution
Southern Africa
Northern Africa
Heat-Shock Response
Lipogenesis
Western Africa
Body Height
Middle East
Livestock
Horns
Growth

Keywords

  • Admixture
  • Africa
  • Fat-tail
  • Ovis aries
  • Thin-tail

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

Cite this

Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep. / Ahbara, Abulgasim; Bahbahani, Hussain; Almathen, Faisal; Al-Abri, Mohammed; Agoub, Mukhtar Omar; Abeba, Ayelle; Kebede, Adebabay; Musa, Hassan Hussein; Mastrangelo, Salvatore; Pilla, Fabio; Ciani, Elena; Hanotte, Olivier; Mwacharo, Joram M.

In: Frontiers in Genetics, Vol. 10, No. JAN, 01.01.2019.

Research output: Contribution to journalArticle

Ahbara, A, Bahbahani, H, Almathen, F, Al-Abri, M, Agoub, MO, Abeba, A, Kebede, A, Musa, HH, Mastrangelo, S, Pilla, F, Ciani, E, Hanotte, O & Mwacharo, JM 2019, 'Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep', Frontiers in Genetics, vol. 10, no. JAN. https://doi.org/10.3389/fgene.2018.00699
Ahbara, Abulgasim ; Bahbahani, Hussain ; Almathen, Faisal ; Al-Abri, Mohammed ; Agoub, Mukhtar Omar ; Abeba, Ayelle ; Kebede, Adebabay ; Musa, Hassan Hussein ; Mastrangelo, Salvatore ; Pilla, Fabio ; Ciani, Elena ; Hanotte, Olivier ; Mwacharo, Joram M. / Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep. In: Frontiers in Genetics. 2019 ; Vol. 10, No. JAN.
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