Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β2 polymorphism in Dupuytren's disease

A. Bayat; A. Alansar; A. H. Hajeer; M. Shah; J. S. Watson; J. K. Stanley; M. W.J. Ferguson; W. E.R. Ollier

doi:10.1054/jhsb.2001.0689

Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β₂ polymorphism in Dupuytren's disease

A. Bayat^*, A. Alansar, A. H. Hajeer, M. Shah, J. S. Watson, J. K. Stanley, M. W.J. Ferguson, W. E.R. Ollier

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ₂ gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ₂ allele frequency distributions between cases and controls for the TGFβ₂ polymorphism.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	Journal of Hand Surgery
Volume	27 B
Issue number	1
DOIs	https://doi.org/10.1054/jhsb.2001.0689
Publication status	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Surgery
Transplantation

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abstract = "The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ2 allele frequency distributions between cases and controls for the TGFβ2 polymorphism.",

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AU - Bayat, A.

AU - Alansar, A.

AU - Hajeer, A. H.

AU - Shah, M.

AU - Watson, J. S.

AU - Stanley, J. K.

AU - Ferguson, M. W.J.

AU - Ollier, W. E.R.

PY - 2002

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AB - The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ2 allele frequency distributions between cases and controls for the TGFβ2 polymorphism.

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JO - Journal of Hand Surgery

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Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β₂ polymorphism in Dupuytren's disease

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