Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease

A. Bayat; A. Alansar; A. H. Hajeer; M. Shah; J. S. Watson; J. K. Stanley; M. W.J. Ferguson; W. E.R. Ollier

doi:10.1054/jhsb.2001.0689

Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease

A. Bayat^*, A. Alansar, A. H. Hajeer, M. Shah, J. S. Watson, J. K. Stanley, M. W.J. Ferguson, W. E.R. Ollier

^*Corresponding author for this work

Biology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ ₂ gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ ₂ allele frequency distributions between cases and controls for the TGFβ ₂ polymorphism.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	Journal of Hand Surgery
Volume	27 B
Issue number	1
DOIs	https://doi.org/10.1054/jhsb.2001.0689
Publication status	Published - 2002

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

Access to Document

10.1054/jhsb.2001.0689

Cite this

Genetic susceptibility in Dupuytren's disease : Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease. / Bayat, A.; Alansar, A.; Hajeer, A. H.; Shah, M.; Watson, J. S.; Stanley, J. K.; Ferguson, M. W.J.; Ollier, W. E.R.

In: Journal of Hand Surgery, Vol. 27 B, No. 1, 2002, p. 47-49.

Research output: Contribution to journal › Article › peer-review

@article{f4cb2fc8393c4891a3c6863352167239,

title = "Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease",

abstract = "The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ 2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ 2 allele frequency distributions between cases and controls for the TGFβ 2 polymorphism.",

author = "A. Bayat and A. Alansar and Hajeer, {A. H.} and M. Shah and Watson, {J. S.} and Stanley, {J. K.} and Ferguson, {M. W.J.} and Ollier, {W. E.R.}",

year = "2002",

doi = "10.1054/jhsb.2001.0689",

language = "English",

volume = "27 B",

pages = "47--49",

journal = "Journal of Hand Surgery",

issn = "0266-7681",

publisher = "SAGE Publications Ltd",

number = "1",

}

TY - JOUR

T1 - Genetic susceptibility in Dupuytren's disease

T2 - Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease

AU - Bayat, A.

AU - Alansar, A.

AU - Hajeer, A. H.

AU - Shah, M.

AU - Watson, J. S.

AU - Stanley, J. K.

AU - Ferguson, M. W.J.

AU - Ollier, W. E.R.

PY - 2002

Y1 - 2002

N2 - The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ 2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ 2 allele frequency distributions between cases and controls for the TGFβ 2 polymorphism.

AB - The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ 2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ 2 allele frequency distributions between cases and controls for the TGFβ 2 polymorphism.

UR - http://www.scopus.com/inward/record.url?scp=0036205665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036205665&partnerID=8YFLogxK

U2 - 10.1054/jhsb.2001.0689

DO - 10.1054/jhsb.2001.0689

M3 - Article

C2 - 11895345

AN - SCOPUS:0036205665

VL - 27 B

SP - 47

EP - 49

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

SN - 0266-7681

IS - 1

ER -

Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this