Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease

A. Bayat, A. Alansar, A. H. Hajeer, M. Shah, J. S. Watson, J. K. Stanley, M. W.J. Ferguson, W. E.R. Ollier

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ 2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ 2 allele frequency distributions between cases and controls for the TGFβ 2 polymorphism.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalJournal of Hand Surgery
Volume27 B
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Dupuytren Contracture
Transforming Growth Factors
Genetic Predisposition to Disease
5' Untranslated Regions
Gene Frequency
Genes
DNA

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Genetic susceptibility in Dupuytren's disease : Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease. / Bayat, A.; Alansar, A.; Hajeer, A. H.; Shah, M.; Watson, J. S.; Stanley, J. K.; Ferguson, M. W.J.; Ollier, W. E.R.

In: Journal of Hand Surgery, Vol. 27 B, No. 1, 2002, p. 47-49.

Research output: Contribution to journalArticle

Bayat, A. ; Alansar, A. ; Hajeer, A. H. ; Shah, M. ; Watson, J. S. ; Stanley, J. K. ; Ferguson, M. W.J. ; Ollier, W. E.R. / Genetic susceptibility in Dupuytren's disease : Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease. In: Journal of Hand Surgery. 2002 ; Vol. 27 B, No. 1. pp. 47-49.
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