Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β 2 polymorphism in Dupuytren's disease

A. Bayat; A. Alansar; A. H. Hajeer; M. Shah; J. S. Watson; J. K. Stanley; M. W.J. Ferguson; W. E.R. Ollier

doi:10.1054/jhsb.2001.0689

Genetic susceptibility in Dupuytren's disease

Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease

A. Bayat, A. Alansar, A. H. Hajeer, M. Shah, J. S. Watson, J. K. Stanley, M. W.J. Ferguson, W. E.R. Ollier

Biology

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ ₂ gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ ₂ allele frequency distributions between cases and controls for the TGFβ ₂ polymorphism.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	Journal of Hand Surgery
Volume	27 B
Issue number	1
DOIs	https://doi.org/10.1054/jhsb.2001.0689
Publication status	Published - 2002

Fingerprint

Dupuytren Contracture

Transforming Growth Factors

Genetic Predisposition to Disease

5' Untranslated Regions

Gene Frequency

Genes

DNA

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

Cite this

Bayat, A., Alansar, A., Hajeer, A. H., Shah, M., Watson, J. S., Stanley, J. K., ... Ollier, W. E. R. (2002). Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease. Journal of Hand Surgery, 27 B(1), 47-49. https://doi.org/10.1054/jhsb.2001.0689

Genetic susceptibility in Dupuytren's disease : Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease. / Bayat, A.; Alansar, A.; Hajeer, A. H.; Shah, M.; Watson, J. S.; Stanley, J. K.; Ferguson, M. W.J.; Ollier, W. E.R.

In: Journal of Hand Surgery, Vol. 27 B, No. 1, 2002, p. 47-49.

Research output: Contribution to journal › Article

Bayat, A, Alansar, A, Hajeer, AH, Shah, M, Watson, JS, Stanley, JK, Ferguson, MWJ & Ollier, WER 2002, 'Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease', Journal of Hand Surgery, vol. 27 B, no. 1, pp. 47-49. https://doi.org/10.1054/jhsb.2001.0689

Bayat A, Alansar A, Hajeer AH, Shah M, Watson JS, Stanley JK et al. Genetic susceptibility in Dupuytren's disease: Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease. Journal of Hand Surgery. 2002;27 B(1):47-49. https://doi.org/10.1054/jhsb.2001.0689

Bayat, A. ; Alansar, A. ; Hajeer, A. H. ; Shah, M. ; Watson, J. S. ; Stanley, J. K. ; Ferguson, M. W.J. ; Ollier, W. E.R. / Genetic susceptibility in Dupuytren's disease : Lack of association of a novel transforming growth factor β ₂ polymorphism in Dupuytren's disease. In: Journal of Hand Surgery. 2002 ; Vol. 27 B, No. 1. pp. 47-49.

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10.1054/jhsb.2001.0689