Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease

Lina Ji, Abha Chauhan, Jerzy Wegiel, Musthafa M. Essa, Ved Chauhan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Gelsolin, a multifunctional actin-binding protein, forms a complex with amyloid-β protein and reduces the amyloid load in the transgenic mouse model of Alzheimer's disease (AD). Gelsolin consists of six homologous domains, which have specific affinities for phosphatidylinositol 4, 5-bisphosphate, calcium, and actin. During apoptosis, gelsolin is cleaved by the caspase-3 resulting in a 48 kDa carboxyl-terminal fragment (gelsolin-CTF). We report here that gelsolin is significantly cleaved in the frontal cortex of individuals with AD as compared to age-matched controls. A positive correlation was observed between the appearance of gelsolin-CTF in frontal cortex and severity of AD. Gelsolin-CTF was also observed in apoptotic SH-SY5Y cells induced by H 2O2 or calcium ionophore A23187. In addition, lipid peroxidation was increased in the frontal cortex of AD suggesting that oxidative stress occurs in AD brain. Taken together, these results suggest that there may be a link among oxidative stress, neuronal apoptosis, and gelsolin cleavage in AD.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalJournal of Alzheimer's Disease
Volume18
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Gelsolin
  • Oxidative stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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