Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis

J. M. White, B. S. Christie, D. Nam, S. Daar, D. R. Higgs

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalJournal of Medical Genetics
Volume30
Issue number5
Publication statusPublished - 1993

Fingerprint

Thalassemia
Erythrocytes
Glucosephosphate Dehydrogenase Deficiency
Sickle Cell Anemia
Pandemics
Southern Blotting
Population
Genes
Malaria
hemoglobin A2'

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

White, J. M., Christie, B. S., Nam, D., Daar, S., & Higgs, D. R. (1993). Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis. Journal of Medical Genetics, 30(5), 396-400.

Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis. / White, J. M.; Christie, B. S.; Nam, D.; Daar, S.; Higgs, D. R.

In: Journal of Medical Genetics, Vol. 30, No. 5, 1993, p. 396-400.

Research output: Contribution to journalArticle

White, JM, Christie, BS, Nam, D, Daar, S & Higgs, DR 1993, 'Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis', Journal of Medical Genetics, vol. 30, no. 5, pp. 396-400.
White, J. M. ; Christie, B. S. ; Nam, D. ; Daar, S. ; Higgs, D. R. / Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis. In: Journal of Medical Genetics. 1993 ; Vol. 30, No. 5. pp. 396-400.
@article{2e6d7f0bff4a414799a886c7d503995a,
title = "Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis",
abstract = "The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.",
author = "White, {J. M.} and Christie, {B. S.} and D. Nam and S. Daar and Higgs, {D. R.}",
year = "1993",
language = "English",
volume = "30",
pages = "396--400",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis

AU - White, J. M.

AU - Christie, B. S.

AU - Nam, D.

AU - Daar, S.

AU - Higgs, D. R.

PY - 1993

Y1 - 1993

N2 - The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.

AB - The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.

UR - http://www.scopus.com/inward/record.url?scp=0027231519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027231519&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 396

EP - 400

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 5

ER -