Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis

J. M. White, B. S. Christie, D. Nam, S. Daar, D. R. Higgs

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Abstract

The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalJournal of Medical Genetics
Volume30
Issue number5
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

White, J. M., Christie, B. S., Nam, D., Daar, S., & Higgs, D. R. (1993). Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis. Journal of Medical Genetics, 30(5), 396-400.