Abstract
The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.
| Original language | English |
|---|---|
| Pages (from-to) | 396-400 |
| Number of pages | 5 |
| Journal | Journal of Medical Genetics |
| Volume | 30 |
| Issue number | 5 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis. / White, J. M.; Christie, B. S.; Nam, D.; Daar, S.; Higgs, D. R.
In: Journal of Medical Genetics, Vol. 30, No. 5, 1993, p. 396-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency and clinical significance of erythrocyte genetic abnormalities in Omanis
AU - White, J. M.
AU - Christie, B. S.
AU - Nam, D.
AU - Daar, S.
AU - Higgs, D. R.
PY - 1993
Y1 - 1993
N2 - The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.
AB - The frequencies of four malaria associated erythrocyte genetic abnormalities have been established in 1000 Omani subjects. They are: homozygous α+ thalassaemia (-α/-α) 0-45; high Hb A2 β thalassaemia trait 0-015; sickle trait (Hb A/S) 0-061; and glucose 6 phosphate dehydrogenase deficiency (Gd-): males 0-27, females 0-11. From our data the α+ (-α/) thal gene (confirmed by Southern blotting) is pandemic in this population. Moreover, in spite of the very high frequency of Gd , oxidative haemolytic syndromes are very uncommon. Also preliminary data indicate that among the Omani population with sickle cell disease, homozygosity of the α+ gene markedly modifies the clinical picture.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027231519&partnerID=8YFLogxK
M3 - Article
VL - 30
SP - 396
EP - 400
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
SN - 0022-2593
IS - 5
ER -