Fluctuation in the levels of immunoglobulin m and immunoglobulin G antibodies for cardiolipin and β2-glycoprotein among healthy pregnant women

Mohammed S. Al-Balushi, Sidgi S. Hasson, Elias A. Said, Juma Z. Al-Busaidi, Muna S. Al-Daihani, Mohammed S. Othman, Talal A. Sallam, Mohammed A. Idris, Moza Al-Kalbani, Nicholas Woodhouse, Ali A. Al-Jabri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Antiphospholipid antibodies fuctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzyme-linked immunosorbent assay. Results: Te ACA IgM levels were significantly higher in the control group compared to the pregnant women (P 2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and 2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.

Original languageEnglish
Pages (from-to)e478-e485
JournalSultan Qaboos University Medical Journal
Volume14
Issue number4
Publication statusPublished - Nov 1 2014

Fingerprint

Cardiolipins
Immunoglobulins
Pregnant Women
Glycoproteins
Immunoglobulin G
Immunoglobulin M
Pregnancy
Antibodies
Control Groups
Anti-Idiotypic Antibodies
Oman
Antiphospholipid Antibodies
Autoimmune Diseases
Enzyme-Linked Immunosorbent Assay
Antigens

Keywords

  • Anticardiolipin antibodies
  • beta 2-glycoprotein I
  • Oman
  • Pregnancy
  • Women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fluctuation in the levels of immunoglobulin m and immunoglobulin G antibodies for cardiolipin and β2-glycoprotein among healthy pregnant women. / Al-Balushi, Mohammed S.; Hasson, Sidgi S.; Said, Elias A.; Al-Busaidi, Juma Z.; Al-Daihani, Muna S.; Othman, Mohammed S.; Sallam, Talal A.; Idris, Mohammed A.; Al-Kalbani, Moza; Woodhouse, Nicholas; Al-Jabri, Ali A.

In: Sultan Qaboos University Medical Journal, Vol. 14, No. 4, 01.11.2014, p. e478-e485.

Research output: Contribution to journalArticle

@article{e20101deeeb44edcb0bfc479105e2f51,
title = "Fluctuation in the levels of immunoglobulin m and immunoglobulin G antibodies for cardiolipin and β2-glycoprotein among healthy pregnant women",
abstract = "Objectives: Antiphospholipid antibodies fuctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzyme-linked immunosorbent assay. Results: Te ACA IgM levels were significantly higher in the control group compared to the pregnant women (P 2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and 2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.",
keywords = "Anticardiolipin antibodies, beta 2-glycoprotein I, Oman, Pregnancy, Women",
author = "Al-Balushi, {Mohammed S.} and Hasson, {Sidgi S.} and Said, {Elias A.} and Al-Busaidi, {Juma Z.} and Al-Daihani, {Muna S.} and Othman, {Mohammed S.} and Sallam, {Talal A.} and Idris, {Mohammed A.} and Moza Al-Kalbani and Nicholas Woodhouse and Al-Jabri, {Ali A.}",
year = "2014",
month = "11",
day = "1",
language = "English",
volume = "14",
pages = "e478--e485",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "4",

}

TY - JOUR

T1 - Fluctuation in the levels of immunoglobulin m and immunoglobulin G antibodies for cardiolipin and β2-glycoprotein among healthy pregnant women

AU - Al-Balushi, Mohammed S.

AU - Hasson, Sidgi S.

AU - Said, Elias A.

AU - Al-Busaidi, Juma Z.

AU - Al-Daihani, Muna S.

AU - Othman, Mohammed S.

AU - Sallam, Talal A.

AU - Idris, Mohammed A.

AU - Al-Kalbani, Moza

AU - Woodhouse, Nicholas

AU - Al-Jabri, Ali A.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Objectives: Antiphospholipid antibodies fuctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzyme-linked immunosorbent assay. Results: Te ACA IgM levels were significantly higher in the control group compared to the pregnant women (P 2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and 2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.

AB - Objectives: Antiphospholipid antibodies fuctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzyme-linked immunosorbent assay. Results: Te ACA IgM levels were significantly higher in the control group compared to the pregnant women (P 2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and 2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.

KW - Anticardiolipin antibodies

KW - beta 2-glycoprotein I

KW - Oman

KW - Pregnancy

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=84907987866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907987866&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84907987866

VL - 14

SP - e478-e485

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 4

ER -