Fluctuation in the levels of immunoglobulin m and immunoglobulin G antibodies for cardiolipin and β2-glycoprotein among healthy pregnant women

Objectives: Antiphospholipid antibodies fuctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β₂-glycoprotein (β₂GP) among healthy pregnant women. Methods: Tis study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β₂GP were measured using a standard enzyme-linked immunosorbent assay. Results: Te ACA IgM levels were significantly higher in the control group compared to the pregnant women (P 2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and 2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.