Flow injection colorimetric method for the assay of vitamin C in drug formulations using tris,1-10-phenanthroline-iron(III) complex as an oxidant in sulfuric acid media

Salah M. Sultan, Abdella M. Abdennabi, Fakhr Eldin O Suliman

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A simple, fast and accurate colorimetric flow injection (FI) method suitable for the assay of vitamin C in drug formulations was proposed. In the method, vitamin C was injected into a flowing stream of iron(III) and then mixed with 1,10-phenanthroline in 0.05M sulphuric acid media. The mixture was allowed to react in a 45-cm long coil and the resulting solution of tris, 1-10-phenanthroline-iron(II) complex was monitored at 510 nm. The method was adopted by fully investigating the kinetics of the reaction and proposing a suitable mechanism. A throughput of 100 samples per hour was achieved with a relative standard deviation of 0.88% for vitamin C concentration range of 100-400 ppm.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalTalanta
Volume41
Issue number1
DOIs
Publication statusPublished - 1994

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Drug Compounding
Oxidants
Ascorbic Acid
Assays
Injections
Iron
Throughput
Kinetics
Acids
sulfuric acid
ferriin
Pharmaceutical Chemistry
1,10-phenanthroline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Flow injection colorimetric method for the assay of vitamin C in drug formulations using tris,1-10-phenanthroline-iron(III) complex as an oxidant in sulfuric acid media. / Sultan, Salah M.; Abdennabi, Abdella M.; Suliman, Fakhr Eldin O.

In: Talanta, Vol. 41, No. 1, 1994, p. 125-130.

Research output: Contribution to journalArticle

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