TY - JOUR
T1 - Flow injection colorimetric method for the assay of vitamin C in drug formulations using tris,1-10-phenanthroline-iron(III) complex as an oxidant in sulfuric acid media
AU - Sultan, Salah M.
AU - Abdennabi, Abdella M.
AU - Suliman, Fakhr Eldin O.
PY - 1994/1
Y1 - 1994/1
N2 - A simple, fast and accurate colorimetric flow injection (FI) method suitable for the assay of vitamin C in drug formulations was proposed. In the method, vitamin C was injected into a flowing stream of iron(III) and then mixed with 1,10-phenanthroline in 0.05M sulphuric acid media. The mixture was allowed to react in a 45-cm long coil and the resulting solution of tris, 1-10-phenanthroline-iron(II) complex was monitored at 510 nm. The method was adopted by fully investigating the kinetics of the reaction and proposing a suitable mechanism. A throughput of 100 samples per hour was achieved with a relative standard deviation of 0.88% for vitamin C concentration range of 100-400 ppm.
AB - A simple, fast and accurate colorimetric flow injection (FI) method suitable for the assay of vitamin C in drug formulations was proposed. In the method, vitamin C was injected into a flowing stream of iron(III) and then mixed with 1,10-phenanthroline in 0.05M sulphuric acid media. The mixture was allowed to react in a 45-cm long coil and the resulting solution of tris, 1-10-phenanthroline-iron(II) complex was monitored at 510 nm. The method was adopted by fully investigating the kinetics of the reaction and proposing a suitable mechanism. A throughput of 100 samples per hour was achieved with a relative standard deviation of 0.88% for vitamin C concentration range of 100-400 ppm.
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U2 - 10.1016/0039-9140(94)80177-0
DO - 10.1016/0039-9140(94)80177-0
M3 - Article
AN - SCOPUS:0001315252
SN - 0039-9140
VL - 41
SP - 125
EP - 130
JO - Talanta
JF - Talanta
IS - 1
ER -