Fetal toxicity of Anastatica hierochuntica L. in mice

R. A. Rasheed, A. K. Bashir, B. H. Ali

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anastatica hiercohuntica L. is a medicinal plant commonly used in the United Arab Emirates for various ailments, such as post-partum bleeding. A lyophilized extract of the plant was administered to pregnant mice (plug=day 0) for 3 consecutive but separate gestation days (GD) 8-9, 10-12, and 12-14, at oral doses of 0.25, 1, and 4g/kg. Controls received saline only, and no abnormalities were seen. Results showed that resorption and excencephaly were the main developmental defects resulting from treatment with the extract. The incidence of excencephaly depended on both the dose and the developmental stage. The gestational period most susceptible to the treatment was GD 12-14, where the doses 0.25, 1, and 4g/kg produced 1(1/100), 2(2/100), and 6.50%(10/154) incidence of excencephaly, respectively. The GD 1012 period was moderately susceptible where the doses 0.25, 1, and 4g/kg produced incidence of 2.2(2/90), 2(2/100), and 2.8% (3/106), respectively. The least susceptible stage of development was GD 8-10, where the above doses produced 0(0/68), 2(2/99), and 2%(2/94) incidences, respectively. In addition to excencephaly, the doses used also induced incidence of fetal resorption. The resorption rates were stage dependent, where treatment with the dose 4g/kg on GD 8-10 was most detrimental, producing about 10.4%(11/105) resorption of the total fetuses examined. Therefore, the plant, at the doses used may be considered teratogenic and embryolethal.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

Fingerprint

Plant Extracts
Toxicity
toxicity
Pregnancy
Defects
Incidence
mice
dosage
pregnancy
resorption
incidence
Fetal Resorption
United Arab Emirates
Medicinal Plants
fetal resorption
Fetus
Hemorrhage
plant extracts
hemorrhage
medicinal plants

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Fetal toxicity of Anastatica hierochuntica L. in mice. / Rasheed, R. A.; Bashir, A. K.; Ali, B. H.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Rasheed, RA, Bashir, AK & Ali, BH 1997, 'Fetal toxicity of Anastatica hierochuntica L. in mice', FASEB Journal, vol. 11, no. 3.
Rasheed, R. A. ; Bashir, A. K. ; Ali, B. H. / Fetal toxicity of Anastatica hierochuntica L. in mice. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
@article{26281a3f7a234c38b9d38a25ece7edff,
title = "Fetal toxicity of Anastatica hierochuntica L. in mice",
abstract = "Anastatica hiercohuntica L. is a medicinal plant commonly used in the United Arab Emirates for various ailments, such as post-partum bleeding. A lyophilized extract of the plant was administered to pregnant mice (plug=day 0) for 3 consecutive but separate gestation days (GD) 8-9, 10-12, and 12-14, at oral doses of 0.25, 1, and 4g/kg. Controls received saline only, and no abnormalities were seen. Results showed that resorption and excencephaly were the main developmental defects resulting from treatment with the extract. The incidence of excencephaly depended on both the dose and the developmental stage. The gestational period most susceptible to the treatment was GD 12-14, where the doses 0.25, 1, and 4g/kg produced 1(1/100), 2(2/100), and 6.50{\%}(10/154) incidence of excencephaly, respectively. The GD 1012 period was moderately susceptible where the doses 0.25, 1, and 4g/kg produced incidence of 2.2(2/90), 2(2/100), and 2.8{\%} (3/106), respectively. The least susceptible stage of development was GD 8-10, where the above doses produced 0(0/68), 2(2/99), and 2{\%}(2/94) incidences, respectively. In addition to excencephaly, the doses used also induced incidence of fetal resorption. The resorption rates were stage dependent, where treatment with the dose 4g/kg on GD 8-10 was most detrimental, producing about 10.4{\%}(11/105) resorption of the total fetuses examined. Therefore, the plant, at the doses used may be considered teratogenic and embryolethal.",
author = "Rasheed, {R. A.} and Bashir, {A. K.} and Ali, {B. H.}",
year = "1997",
language = "English",
volume = "11",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Fetal toxicity of Anastatica hierochuntica L. in mice

AU - Rasheed, R. A.

AU - Bashir, A. K.

AU - Ali, B. H.

PY - 1997

Y1 - 1997

N2 - Anastatica hiercohuntica L. is a medicinal plant commonly used in the United Arab Emirates for various ailments, such as post-partum bleeding. A lyophilized extract of the plant was administered to pregnant mice (plug=day 0) for 3 consecutive but separate gestation days (GD) 8-9, 10-12, and 12-14, at oral doses of 0.25, 1, and 4g/kg. Controls received saline only, and no abnormalities were seen. Results showed that resorption and excencephaly were the main developmental defects resulting from treatment with the extract. The incidence of excencephaly depended on both the dose and the developmental stage. The gestational period most susceptible to the treatment was GD 12-14, where the doses 0.25, 1, and 4g/kg produced 1(1/100), 2(2/100), and 6.50%(10/154) incidence of excencephaly, respectively. The GD 1012 period was moderately susceptible where the doses 0.25, 1, and 4g/kg produced incidence of 2.2(2/90), 2(2/100), and 2.8% (3/106), respectively. The least susceptible stage of development was GD 8-10, where the above doses produced 0(0/68), 2(2/99), and 2%(2/94) incidences, respectively. In addition to excencephaly, the doses used also induced incidence of fetal resorption. The resorption rates were stage dependent, where treatment with the dose 4g/kg on GD 8-10 was most detrimental, producing about 10.4%(11/105) resorption of the total fetuses examined. Therefore, the plant, at the doses used may be considered teratogenic and embryolethal.

AB - Anastatica hiercohuntica L. is a medicinal plant commonly used in the United Arab Emirates for various ailments, such as post-partum bleeding. A lyophilized extract of the plant was administered to pregnant mice (plug=day 0) for 3 consecutive but separate gestation days (GD) 8-9, 10-12, and 12-14, at oral doses of 0.25, 1, and 4g/kg. Controls received saline only, and no abnormalities were seen. Results showed that resorption and excencephaly were the main developmental defects resulting from treatment with the extract. The incidence of excencephaly depended on both the dose and the developmental stage. The gestational period most susceptible to the treatment was GD 12-14, where the doses 0.25, 1, and 4g/kg produced 1(1/100), 2(2/100), and 6.50%(10/154) incidence of excencephaly, respectively. The GD 1012 period was moderately susceptible where the doses 0.25, 1, and 4g/kg produced incidence of 2.2(2/90), 2(2/100), and 2.8% (3/106), respectively. The least susceptible stage of development was GD 8-10, where the above doses produced 0(0/68), 2(2/99), and 2%(2/94) incidences, respectively. In addition to excencephaly, the doses used also induced incidence of fetal resorption. The resorption rates were stage dependent, where treatment with the dose 4g/kg on GD 8-10 was most detrimental, producing about 10.4%(11/105) resorption of the total fetuses examined. Therefore, the plant, at the doses used may be considered teratogenic and embryolethal.

UR - http://www.scopus.com/inward/record.url?scp=33750226621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750226621&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33750226621

VL - 11

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -