Feline Orthopoxvirus infection transmitted from cat to human

Thomas Hawranek, Manfred Tritscher, Wolfgang H. Muss, Julia Jecel, Norbert Nowotny, Jolanta Kolodziejek, Michael Emberger, Herwig Schaeppi, Helmut Hintner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We report the case of a 56-year-old female patient who presented with an inflamed, ulcerated lesion on the left side of her neck after contact (scratch) with a cat living in the patient's house. Satellite lesions developed despite local treatment and parenteral clindamycin. Histopatholgic examination and the Tzanck test showed evidence of a viral infection. Subsequent transmission electron microscopy of scrap tissue and material from a fresh pustule exhibited multiple typical poxvirus particles, predominantly in remnants of scaled-off layers of degenerated keratinocytes, and virus particles in intermingled phagocytes, leading to the diagnosis of feline Orthopoxvirus (cowpox virus) infection. These results were verified by polymerase chain reaction and sequencing. Concern has been raised as to whether discontinuation of smallpox vaccine would cause an increase in Orthopoxvirus infection, but this has not yet shown to be the case.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume49
Issue number3
DOIs
Publication statusPublished - Sep 1 2003

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Orthopoxvirus
Felidae
Virus Diseases
Cats
Cowpox virus
Smallpox Vaccine
Poxviridae
Clindamycin
Phagocytes
Infection
Transmission Electron Microscopy
Keratinocytes
Virion
Neck
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Hawranek, T., Tritscher, M., Muss, W. H., Jecel, J., Nowotny, N., Kolodziejek, J., ... Hintner, H. (2003). Feline Orthopoxvirus infection transmitted from cat to human. Journal of the American Academy of Dermatology, 49(3), 513-518. https://doi.org/10.1067/S0190-9622(03)00762-X

Feline Orthopoxvirus infection transmitted from cat to human. / Hawranek, Thomas; Tritscher, Manfred; Muss, Wolfgang H.; Jecel, Julia; Nowotny, Norbert; Kolodziejek, Jolanta; Emberger, Michael; Schaeppi, Herwig; Hintner, Helmut.

In: Journal of the American Academy of Dermatology, Vol. 49, No. 3, 01.09.2003, p. 513-518.

Research output: Contribution to journalArticle

Hawranek, T, Tritscher, M, Muss, WH, Jecel, J, Nowotny, N, Kolodziejek, J, Emberger, M, Schaeppi, H & Hintner, H 2003, 'Feline Orthopoxvirus infection transmitted from cat to human', Journal of the American Academy of Dermatology, vol. 49, no. 3, pp. 513-518. https://doi.org/10.1067/S0190-9622(03)00762-X
Hawranek, Thomas ; Tritscher, Manfred ; Muss, Wolfgang H. ; Jecel, Julia ; Nowotny, Norbert ; Kolodziejek, Jolanta ; Emberger, Michael ; Schaeppi, Herwig ; Hintner, Helmut. / Feline Orthopoxvirus infection transmitted from cat to human. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 49, No. 3. pp. 513-518.
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