TY - JOUR
T1 - Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer
AU - Malgundkar, Shika Hanif
AU - Tamimi, Yahya
N1 - Publisher Copyright:
© 2023 The Authors.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.
AB - More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.
KW - biomarkers
KW - cell-free messengers
KW - exosomes
KW - molecular cargo
KW - ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=85151876025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151876025&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/c4cc48cb-7618-3e61-926e-d1676845e260/
U2 - 10.2144/fsoa-2022-0032
DO - 10.2144/fsoa-2022-0032
M3 - Review article
C2 - 37006229
AN - SCOPUS:85151876025
SN - 2056-5623
VL - 9
JO - Future Science OA
JF - Future Science OA
IS - 1
M1 - 157
ER -
