Excitotoxicity in the pathogenesis of autism

M. M. Essa, Nady Braidy, S. Subash, R. K. Vijayan, Gilles J. Guillemin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a neurodevelopmental disorder characterized by stereotyped interests and behaviors and abnormalities in verbal and nonverbal communication. Autism is reported as a multifactorial disorder resulting from interactions between genetic, environmental, and immunological factors. Excitotoxicity and oxidative stress are potential mechanisms, which are likely to serve as a converging point to these risk factors. Numerous studies suggest that excitotoxicity is a likely cause of neuronal dysfunction in autistic patients. Glutamate is the main excitatory neurotransmitter generated in the CNS, and overactivation of glutamate receptors triggers excitotoxicity. Hyperactivation of glutamatergic receptors, NMDA and AMPA, leads to activation of enzymes, which damage cellular structure, membrane permeability, and electrochemical gradients. The role of excitotoxicity in autistic subjects is summarized in this chapter.

Original languageEnglish
Title of host publicationHandbook of Neurotoxicity
PublisherSpringer New York
Pages1267-1271
Number of pages5
Volume2
ISBN (Electronic)9781461458364
ISBN (Print)9781461458357
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Autistic Disorder
Nonverbal Communication
Stereotyped Behavior
Enzyme Activation
AMPA Receptors
Glutamate Receptors
Immunologic Factors
Cellular Structures
N-Methyl-D-Aspartate Receptors
Neurotransmitter Agents
Glutamic Acid
Permeability
Oxidative Stress
Membranes
Neurodevelopmental Disorders

Keywords

  • Autism
  • Excitotoxicity
  • Free radicals
  • Glutamatergic receptors
  • Ion channel
  • Membrane potential
  • Neurotransmitter

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Essa, M. M., Braidy, N., Subash, S., Vijayan, R. K., & Guillemin, G. J. (2014). Excitotoxicity in the pathogenesis of autism. In Handbook of Neurotoxicity (Vol. 2, pp. 1267-1271). Springer New York. https://doi.org/10.1007/978-1-4614-5836-4_148

Excitotoxicity in the pathogenesis of autism. / Essa, M. M.; Braidy, Nady; Subash, S.; Vijayan, R. K.; Guillemin, Gilles J.

Handbook of Neurotoxicity. Vol. 2 Springer New York, 2014. p. 1267-1271.

Research output: Chapter in Book/Report/Conference proceedingChapter

Essa, MM, Braidy, N, Subash, S, Vijayan, RK & Guillemin, GJ 2014, Excitotoxicity in the pathogenesis of autism. in Handbook of Neurotoxicity. vol. 2, Springer New York, pp. 1267-1271. https://doi.org/10.1007/978-1-4614-5836-4_148
Essa MM, Braidy N, Subash S, Vijayan RK, Guillemin GJ. Excitotoxicity in the pathogenesis of autism. In Handbook of Neurotoxicity. Vol. 2. Springer New York. 2014. p. 1267-1271 https://doi.org/10.1007/978-1-4614-5836-4_148
Essa, M. M. ; Braidy, Nady ; Subash, S. ; Vijayan, R. K. ; Guillemin, Gilles J. / Excitotoxicity in the pathogenesis of autism. Handbook of Neurotoxicity. Vol. 2 Springer New York, 2014. pp. 1267-1271
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