TY - JOUR
T1 - Estrogen receptor-negative breast ductal carcinoma
T2 - Clinicopathological features and Mib-1 (Ki-67) proliferative index association
AU - MdPaiman, Noorasmaliza
AU - Md Ali, Siti Aishah
AU - MdZin, Reena
AU - Kamal, Meor Zamari Meor
AU - Md Amin, Wan Anna
AU - Nallusamy, Mohan
AU - Puspanathan, Pavitratha
AU - Muhammad, Rohaizak
AU - Wan Puteh, Sharifa Ezat
AU - Das, Srijit
PY - 2014/2/28
Y1 - 2014/2/28
N2 - Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.
AB - Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.
UR - http://www.scopus.com/inward/record.url?scp=84896504677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896504677&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0089172
DO - 10.1371/journal.pone.0089172
M3 - Article
C2 - 24586570
AN - SCOPUS:84896504677
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 2
M1 - e89172
ER -
