Equine rhinovirus serotypes 1 and 2

Relationship to each other and to aphthoviruses and cardioviruses

G. Wutz, H. Auer, N. Nowotny, B. Grosse, T. Skern, E. Kuechler

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV.

Original languageEnglish
Pages (from-to)1719-1730
Number of pages12
JournalJournal of General Virology
Volume77
Issue number8
Publication statusPublished - Aug 1996

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Aphthovirus
Cardiovirus
Foot-and-Mouth Disease Virus
Rhinovirus
Horses
Picornaviridae
Encephalomyocarditis virus
Common Cold
Proteins
Poly A
Systems Biology
Viremia
Infection
Respiratory Tract Infections
Serogroup
Organism Cloning
Complementary DNA
Genome
Viruses

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Equine rhinovirus serotypes 1 and 2 : Relationship to each other and to aphthoviruses and cardioviruses. / Wutz, G.; Auer, H.; Nowotny, N.; Grosse, B.; Skern, T.; Kuechler, E.

In: Journal of General Virology, Vol. 77, No. 8, 08.1996, p. 1719-1730.

Research output: Contribution to journalArticle

Wutz, G, Auer, H, Nowotny, N, Grosse, B, Skern, T & Kuechler, E 1996, 'Equine rhinovirus serotypes 1 and 2: Relationship to each other and to aphthoviruses and cardioviruses', Journal of General Virology, vol. 77, no. 8, pp. 1719-1730.
Wutz, G. ; Auer, H. ; Nowotny, N. ; Grosse, B. ; Skern, T. ; Kuechler, E. / Equine rhinovirus serotypes 1 and 2 : Relationship to each other and to aphthoviruses and cardioviruses. In: Journal of General Virology. 1996 ; Vol. 77, No. 8. pp. 1719-1730.
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