Enhancement of Lewis lung carcinoma by the concomitant infection of the host with herpes simplex virus type 1 and type 2

R. J. Reiss Gutfreund, V. Dostal, N. R. Nowotny

Research output: Contribution to journalArticle

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Abstract

Infection with herpes simplex virus (HSV) enhances the growth of Lewis lung tumor (LLT). Infection with HSV-1 enhances as efficiently as HSV-2. A significant acceleration of primary tumor formation was obtained. In mice, lung metastases were increased in number and size above the controls. Enhancement occurred only with high doses of infectious virus and was also obtained only when the virus infection was at a site close to that of the tumor implantation. This finding, in addition to the lack of antigenicity of LLT, is interpreted as arguing against an immunologic mechanism of the phenomenon.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalOncology
Volume40
Issue number1
Publication statusPublished - 1983

Fingerprint

Lewis Lung Carcinoma
Human Herpesvirus 2
Human Herpesvirus 1
Infection
Lung
Neoplasms
Virus Diseases
Simplexvirus
Neoplasm Metastasis
Viruses
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Enhancement of Lewis lung carcinoma by the concomitant infection of the host with herpes simplex virus type 1 and type 2. / Reiss Gutfreund, R. J.; Dostal, V.; Nowotny, N. R.

In: Oncology, Vol. 40, No. 1, 1983, p. 46-51.

Research output: Contribution to journalArticle

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