Emerging bacterial resistance patterns in febrile neutropenic patients: Experience at a tertiary care hospital in Pakistan

M. A. Khan, B. K. Siddiqui, A. Shamim, M. A. Yosuf, U. Ahmed, N. Zakiullah, I. A. Burney

Research output: Contribution to journalArticle

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Abstract

Objective: To look at the clinical presentations, spectrum and site of isolation of the organisms, sensitivity patterns of the organisms and the antibiotic prescribing practices for the treatment of febrile neutropenic patients at our hospital. Methods: The data were collected retrospectively from the records of all neutropenic patients with an absolute neutrophil count (ANC) of less than 500/ml admitted during the period of 3 years from August 1999 to July 2002 at AKUH. Results: Out of the total of 404 patients, 65% had hematological malignancies and around half of them had leukaemia, 86% of the patients presented with fever. A total of 124 bacterial organisms were isolated from 96 patients among which 47% were gram positive and 53% were gram negative organisms; 16.1% of the patients had septicaemia. Coagulase Negative Staphylococci (CoNS) were the most common gram positive and E coli was the most commonly isolated gram negative organism. Most of the gram positive organisms were isolated from blood (67%). There was emerging resistance to all commonly used antibiotics including imipenem, cloxacillin, vancomycin and amikacin. The average duration of neutropenia was 6.4 days. The mortality rate was 6%. Conclusion: There is increasing trend of gram negative organisms developing resistance to commonly used antibiotics. Gram positive bacteria including Enterococcus spp. and CoNS are also showing emerging resistance to vancomycin.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalJournal of the Pakistan Medical Association
Volume54
Issue number7
Publication statusPublished - Jul 2004

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Pakistan
Tertiary Healthcare
Tertiary Care Centers
Fever
Coagulase
Anti-Bacterial Agents
Staphylococcus
Cloxacillin
Vancomycin Resistance
Amikacin
Imipenem
Enterococcus
Gram-Positive Bacteria
Hematologic Neoplasms
Vancomycin
Neutropenia
Sepsis
Leukemia
Neutrophils
Escherichia coli

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Emerging bacterial resistance patterns in febrile neutropenic patients : Experience at a tertiary care hospital in Pakistan. / Khan, M. A.; Siddiqui, B. K.; Shamim, A.; Yosuf, M. A.; Ahmed, U.; Zakiullah, N.; Burney, I. A.

In: Journal of the Pakistan Medical Association, Vol. 54, No. 7, 07.2004, p. 357-360.

Research output: Contribution to journalArticle

Khan, M. A. ; Siddiqui, B. K. ; Shamim, A. ; Yosuf, M. A. ; Ahmed, U. ; Zakiullah, N. ; Burney, I. A. / Emerging bacterial resistance patterns in febrile neutropenic patients : Experience at a tertiary care hospital in Pakistan. In: Journal of the Pakistan Medical Association. 2004 ; Vol. 54, No. 7. pp. 357-360.
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