Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

Karin Sekulin, Angela Hafner-Marx, Jolanta Kolodziejek, Dirk Janik, Peter Schmidt, Norbert Nowotny

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2. years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.

Original languageEnglish
Pages (from-to)399-401
Number of pages3
JournalVeterinary Journal
Volume187
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Keywords

  • Badger
  • Canine distemper virus
  • Genetic variation
  • Haemagglutinin
  • Red fox
  • Wildlife

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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