Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

Karin Sekulin; Angela Hafner-Marx; Jolanta Kolodziejek; Dirk Janik; Peter Schmidt; Norbert Nowotny

doi:10.1016/j.tvjl.2009.12.029

Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

Karin Sekulin, Angela Hafner-Marx, Jolanta Kolodziejek, Dirk Janik, Peter Schmidt, Norbert Nowotny^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2. years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.

Original language	English
Pages (from-to)	399-401
Number of pages	3
Journal	Veterinary Journal
Volume	187
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2009.12.029
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

Badger
Canine distemper virus
Genetic variation
Haemagglutinin
Red fox
Wildlife

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Access to Document

10.1016/j.tvjl.2009.12.029

Cite this

@article{f61db90cb77e42169d4419aa1c2d7195,

title = "Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein",

abstract = "A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2. years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.",

keywords = "Badger, Canine distemper virus, Genetic variation, Haemagglutinin, Red fox, Wildlife",

author = "Karin Sekulin and Angela Hafner-Marx and Jolanta Kolodziejek and Dirk Janik and Peter Schmidt and Norbert Nowotny",

year = "2011",

month = mar,

doi = "10.1016/j.tvjl.2009.12.029",

language = "English",

volume = "187",

pages = "399--401",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

number = "3",

}

TY - JOUR

T1 - Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

AU - Sekulin, Karin

AU - Hafner-Marx, Angela

AU - Kolodziejek, Jolanta

AU - Janik, Dirk

AU - Schmidt, Peter

AU - Nowotny, Norbert

PY - 2011/3

Y1 - 2011/3

N2 - A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2. years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.

AB - A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2. years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.

KW - Badger

KW - Canine distemper virus

KW - Genetic variation

KW - Haemagglutinin

KW - Red fox

KW - Wildlife

UR - http://www.scopus.com/inward/record.url?scp=79951956565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951956565&partnerID=8YFLogxK

U2 - 10.1016/j.tvjl.2009.12.029

DO - 10.1016/j.tvjl.2009.12.029

M3 - Article

C2 - 20089424

AN - SCOPUS:79951956565

SN - 1090-0233

VL - 187

SP - 399

EP - 401

JO - Veterinary Journal

JF - Veterinary Journal

IS - 3

ER -

Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this