Effects of three phamaceuticals on the responses of tadpoles to predator alarm cues

Research output: Contribution to journalArticle

Abstract

The aim of this study is to measure the effects of two selective serotonin reuptake inhibitors, fluoxetine and sertraline, and one selective serotonin and norepinephrine reuptake inhibitor, venlafaxine, on the swimming and lateralization behaviour of Sclerophrys arabica tadpoles exposed to predator alarm cues. Tadpoles were exposed to the three pharmaceuticals either at 0.5 µg/L or 2.0 µg/L, either individually or as a mixture for 14 days. Control tadpoles and those exposed to high concentration of drugs individually or as a mixture, and those exposed to the low-concertation mixture reduced their swimming speed. Tadpoles exposed to 0.5 µg/L fluoxetine or venlafaxine did not respond to the alarm cues. Tadpoles exposed to the mixture had similar responses to that of the control. Results indicate that these drugs have an additive mode of action. Tadpoles exposed to the low-concentration mixture increased lateralization of movement.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalToxicological and Environmental Chemistry
Volume100
Issue number2
DOIs
Publication statusPublished - Feb 7 2018

Fingerprint

Cues
Larva
drug
Fluoxetine
predator
inhibitor
Pharmaceutical Preparations
Sertraline
Serotonin Uptake Inhibitors
Norepinephrine
Drug products
alarm
effect
Venlafaxine Hydrochloride
Low's mixture
Swimming
speed
Serotonin and Noradrenaline Reuptake Inhibitors

Keywords

  • alarm cues
  • behaviour
  • lateralization
  • predator
  • Tadpoles SSRIs

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Effects of three phamaceuticals on the responses of tadpoles to predator alarm cues. / Barry, Michael.

In: Toxicological and Environmental Chemistry, Vol. 100, No. 2, 07.02.2018, p. 205-213.

Research output: Contribution to journalArticle

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