Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats

B. H. Ali, A. K. Bashir

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effect of administration of superoxide dismutase (SOD) on gentamicin nephrotoxicity was examined in rats. SOD was administered at a dose of 2000 i.u/kg or 8000 i.u/kg for 10 consecutive days, and nephrotoxicity was induced by daily i.m. injections of gentamicin at a dose of 80 mg/kg during the last 6 days of the experimental period. Gentamicin induced significant increases in plasma creatinine and urea and protein urinary concentrations, and significant decreases in creatinine clearance and kidney cortical alkaline phosphatase activity and reduced glutathione (GSH) concentrations. The antibiotic also produced marked necrosis of the renal proximal tubules. SOD treatment (8000 i.u/kg) reversed most of these variables, indicating that it was effective in ameliorating gentamicin nephrotoxicity. However, at a dose of 2000 i.u./kg it was mostly ineffective.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalGeneral Pharmacology
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 1996

Keywords

  • gentamicin
  • nephrotoxicity
  • superoxide dismutase

ASJC Scopus subject areas

  • Pharmacology

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