Effect of Psidium guajava leaves on some aspects of the central nervous system in mice

Huda M. Shaheen, Badreldin H. Ali, Ali A. Alqarawi, Ahmed K. Bashir

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The present work examines the effects of hexane, ethyl acetate and methanol extracts of Psidium guajava leaves (20,100,500 and 1250 mg/kg) on the central nervous system in mice. The three extracts exhibited mostly dose-dependent antinociceptive effects in chemical and thermal tests of analgesia. The extracts also produced dose-dependent prolongation of pentobarbitone-induced sleeping time. However, they had variable and mostly non-significant effects on locomotor coordination, locomotor activity or exploration. In the pharmacological tests used, the ethyl acetate extract seemed to be the most active, followed by the hexane and then the methanol extracts. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalPhytotherapy Research
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2000

Fingerprint

Psidium
Neurology
Hexanes
Methanol
Central Nervous System
Pentobarbital
Pain Measurement
Locomotion
Hot Temperature
Pharmacology
ethyl acetate

Keywords

  • Analgesia
  • Exploration
  • Motor activity
  • Psidium guajava
  • Sedation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. / Shaheen, Huda M.; Ali, Badreldin H.; Alqarawi, Ali A.; Bashir, Ahmed K.

In: Phytotherapy Research, Vol. 14, No. 2, 03.2000, p. 107-111.

Research output: Contribution to journalArticle

Shaheen, Huda M. ; Ali, Badreldin H. ; Alqarawi, Ali A. ; Bashir, Ahmed K. / Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. In: Phytotherapy Research. 2000 ; Vol. 14, No. 2. pp. 107-111.
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