EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICS

D. G. Wong, L. Lamki, J. D. Spence, D. Freeman, J. W D Mcdonald

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The effect of sulindac on renal function and blood pressure was compared with those of placebo, piroxicam, and naproxen in 20 patients with primary hypertension being treated with a diuretic and a beta-blocker. Although the three non-steroidal anti-inflammatory drugs (NSAIDs) did not differ in their effect on renal function (weight, glomerular filtration rate, creatinine clearance) or on serum thromboxane and plasma 6-keto prostaglandin F (6-keto PGF), blood pressure was significantly lower with sulindac than with placebo, piroxicam, or naproxen. These differences were associated with less renal cyclooxygenase inhibition by sulindac (reflected by urinary thromboxane B2 and 6-keto PGF) than by other NSAIDs. The findings suggest that the blood pressure differences reflect vasodilation due to differences in the balance between systemic and renal effects of the NSAIDs.

Original languageEnglish
Pages (from-to)997-1001
Number of pages5
JournalThe Lancet
Volume327
Issue number8488
DOIs
Publication statusPublished - May 3 1986

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Drug and Narcotic Control
Sulindac
Diuretics
Anti-Inflammatory Agents
Hypertension
Kidney
Piroxicam
Naproxen
Blood Pressure
Placebos
Pharmaceutical Preparations
Thromboxane B2
Thromboxanes
Prostaglandin-Endoperoxide Synthases
Glomerular Filtration Rate
Vasodilation
Creatinine
Weights and Measures
Serum
prostaglandin F1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICS. / Wong, D. G.; Lamki, L.; Spence, J. D.; Freeman, D.; Mcdonald, J. W D.

In: The Lancet, Vol. 327, No. 8488, 03.05.1986, p. 997-1001.

Research output: Contribution to journalArticle

Wong, D. G. ; Lamki, L. ; Spence, J. D. ; Freeman, D. ; Mcdonald, J. W D. / EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICS. In: The Lancet. 1986 ; Vol. 327, No. 8488. pp. 997-1001.
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