Effect of methotrexate on pulmonary function in patients with rheumatoid arthritis - A prospective study

M. Khadadah, B. Jayakrishnan, S. Al-Gorair, M. Al-Mutairi, N. Al-Maradni, B. Onadeko, A. Malaviya

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If given in high doses, methotrexate (MTX), a folate antagonist, could cause pulmonary complications. To evaluate the pulmonary effects of low-dose methotrexate, 55 newly diagnosed patients with rheumatoid arthritis (RA) prescribed with MTX were studied prospectively. A significant reduction in percent predicted values of forced expiratory volume (FEV1), forced vital capacity (FVC), total lung capacity (TLC), and functional residual capacity (FRC) was observed after 2 years of MTX treatment. A significant increase in the FEV1:FVC ratio was also observed. In comparison to the normal annual decline in healthy adults, the actual reduction in observed values in the patients was significantly greater (3.2, 6.3, and 6.7 times normal for FEV1, FVC, and TLC, respectively). PaO2 and oxygen saturation showed marginal but significant improvement. It was concluded that low-dose MTX treatment in RA might cause an accelerated decline in lung function. Therefore, periodic monitoring of pulmonary function among RA patients started on MTX could be necessary.

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalRheumatology International
Issue number5
Publication statusPublished - 2002



  • Methotrexate
  • Pulmonary function test
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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