Effect of melatonin on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats with reference to biochemical circadian rhythms

K. B. Dakshayani, P. Subramanian, M. Mohamed Essa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tumors and tumor-bearing hosts exhibit markedly altered circadian rhythms, which serve as markers in the early diagnosis and prognosis of cancer. Our study presents the effect of melatonin on circadian rhythms of lipid peroxides and antioxidants in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The circadian rhythm characteristics (acrophase, amplitude, and mesor) of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) were markedly altered in NDEA-treated rats. Melatonin administration caused a significant increase in the amplitude and mesor values of antioxidants and a significant decrease in the mesor values of TBARS. Further delays in acrophase in NDEA-treated rats were reversed by melatonin administration. In conclusion, melatonin may exert its chemopreventive effect by its role as an antioxidant as well as by altering the circadian rhythm characteristics.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalToxicology Mechanisms and Methods
Volume17
Issue number2
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Diethylnitrosamine
Melatonin
Circadian Rhythm
Rats
Thiobarbituric Acid Reactive Substances
Antioxidants
Tumors
Bearings (structural)
Lipid Peroxides
Glutathione Peroxidase
Early Detection of Cancer
Catalase
Superoxide Dismutase
Glutathione
Neoplasms

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Effect of melatonin on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats with reference to biochemical circadian rhythms. / Dakshayani, K. B.; Subramanian, P.; Essa, M. Mohamed.

In: Toxicology Mechanisms and Methods, Vol. 17, No. 2, 03.2007, p. 67-75.

Research output: Contribution to journalArticle

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