Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex

A. A. Abdel-Gayoum, B. H. Ali, K. M. Abdel-Razig, A. A. Bashir, K. Ghywarsha

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rats were injected with gentamicin at doses of 20, 40 and 80 mg/kg per day for 6 consecutive days. The treatment caused nephrotoxicity as evidenced by dose-related increases in serum creatinine concentration and renal tubular necrosis. The nephrotoxicity was accompanied by reduced renal cortical and fasting blood glucose levels, and by increases in serum lactate concentrations. The activities of cortical malate dehydrogenase and alanine transaminase were significantly reduced by the three doses of gentamicin. On the other hand, aspartate transaminase activity was lowered only by the highest dose of antibiotic used. However, the activity of cortical glucose-6-phosphate dehydrogenase was altered by the 20 and 40 mg/kg doses of gentamicin, but not by the 80 mg/kg dose. The two lower doses reduced the lactate content of the cortex but activated lactate dehydrogenase. The activity of isocitrate dehydrogenase was not altered by any of the gentamicin doses used.

Original languageEnglish
Pages (from-to)643-647
Number of pages5
JournalArchives of Toxicology
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 1994

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Metabolic Networks and Pathways
Gentamicins
Rats
Carbohydrates
Kidney
Lactic Acid
Isocitrate Dehydrogenase
Malate Dehydrogenase
Glucosephosphate Dehydrogenase
Aspartate Aminotransferases
Serum
Alanine Transaminase
L-Lactate Dehydrogenase
Blood Glucose
Fasting
Creatinine
Necrosis
Anti-Bacterial Agents

Keywords

  • Carbohydrate metabolism
  • Gentamicin
  • Nephrotoxicity
  • Rat
  • Renal cortex

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex. / Abdel-Gayoum, A. A.; Ali, B. H.; Abdel-Razig, K. M.; Bashir, A. A.; Ghywarsha, K.

In: Archives of Toxicology, Vol. 68, No. 10, 10.1994, p. 643-647.

Research output: Contribution to journalArticle

Abdel-Gayoum, A. A. ; Ali, B. H. ; Abdel-Razig, K. M. ; Bashir, A. A. ; Ghywarsha, K. / Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex. In: Archives of Toxicology. 1994 ; Vol. 68, No. 10. pp. 643-647.
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