Dynamic model of micropipettes in piezo-assisted ICSI

Issam M. Bahadur, James K. Mills

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane's method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.

Original languageEnglish
Title of host publication2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings
Pages191-196
Number of pages6
DOIs
Publication statusPublished - 2012
Event6th International Conference on Complex Medical Engineering, CME 2012 - Kobe, Japan
Duration: Jul 1 2012Jul 4 2012

Other

Other6th International Conference on Complex Medical Engineering, CME 2012
CountryJapan
CityKobe
Period7/1/127/4/12

Fingerprint

Dynamic models
Glass
Piezoelectric actuators
Nonlinear equations
Equations of motion
Drag
Hydrodynamics
Damping

Keywords

  • Kane's method
  • microdissection
  • microinjection
  • piezo-assisted ICSI

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Bahadur, I. M., & Mills, J. K. (2012). Dynamic model of micropipettes in piezo-assisted ICSI. In 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings (pp. 191-196). [6275659] https://doi.org/10.1109/ICCME.2012.6275659

Dynamic model of micropipettes in piezo-assisted ICSI. / Bahadur, Issam M.; Mills, James K.

2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings. 2012. p. 191-196 6275659.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bahadur, IM & Mills, JK 2012, Dynamic model of micropipettes in piezo-assisted ICSI. in 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings., 6275659, pp. 191-196, 6th International Conference on Complex Medical Engineering, CME 2012, Kobe, Japan, 7/1/12. https://doi.org/10.1109/ICCME.2012.6275659
Bahadur IM, Mills JK. Dynamic model of micropipettes in piezo-assisted ICSI. In 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings. 2012. p. 191-196. 6275659 https://doi.org/10.1109/ICCME.2012.6275659
Bahadur, Issam M. ; Mills, James K. / Dynamic model of micropipettes in piezo-assisted ICSI. 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings. 2012. pp. 191-196
@inproceedings{fa0ca025fa5b4f1abbb09bf682100d2d,
title = "Dynamic model of micropipettes in piezo-assisted ICSI",
abstract = "In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane's method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.",
keywords = "Kane's method, microdissection, microinjection, piezo-assisted ICSI",
author = "Bahadur, {Issam M.} and Mills, {James K.}",
year = "2012",
doi = "10.1109/ICCME.2012.6275659",
language = "English",
isbn = "9781467316163",
pages = "191--196",
booktitle = "2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings",

}

TY - GEN

T1 - Dynamic model of micropipettes in piezo-assisted ICSI

AU - Bahadur, Issam M.

AU - Mills, James K.

PY - 2012

Y1 - 2012

N2 - In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane's method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.

AB - In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane's method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.

KW - Kane's method

KW - microdissection

KW - microinjection

KW - piezo-assisted ICSI

UR - http://www.scopus.com/inward/record.url?scp=84867639659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867639659&partnerID=8YFLogxK

U2 - 10.1109/ICCME.2012.6275659

DO - 10.1109/ICCME.2012.6275659

M3 - Conference contribution

AN - SCOPUS:84867639659

SN - 9781467316163

SP - 191

EP - 196

BT - 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings

ER -