Does long term supplementation of Vitamin E cause detrimental effects on the central nervous system? Morphological and histological study in experimental male Wistar rats

Y. Mohamad Fairuz, A. Azian, M. T. Nursiati, D. Srijit, A. H. Hamzaini, W. N. Wan Zurinah, Mazlan Musalmah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Aim. Aging is attributed to neuronal loss associated with increased oxidative stress. Vitamin E, and in particular, tocotrienol are potent antioxidants, which have been shown to be neuroprotective. The main aim of the present study was to observe the effect of long term intake of vitamin E in the form of tocotrienol rich fraction (TRF) and refined, bleached, deodorized palm olein (RBDPO) on the brain of experimental rats. Materials and Methods. Thirty male Wistar rats aged 3 months were either supplemented with TRF (dose of 200mg/kg body weight), RBDPO (dose of 1ml/kg body weight) or distilled water, continuously for 8 months. The animals were then examined in vivo for clinical magnetic resonance imaging (MRI) studies before being sacrificed. The brain was extracted, measured and studied for histological changes. Results. The magnetic resonance imaging (MRI) scan of the lateral ventricle, cortical thickness of cingulate gyrus and hippocampus size did not show any significant changes in all three groups. The brain weight, length and width as well as histological sections of the brain showed no significant changes between the groups. Conclusion. It is thereby concluded that chronic consumption of vitamin E was not detrimental to the central nervous system.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalClinica Terapeutica
Issue number2
Publication statusPublished - 2013
Externally publishedYes


  • Antioxidants
  • Brain
  • Oxidative stress
  • Rats
  • Tocotrienol
  • Vitamin E

ASJC Scopus subject areas

  • Medicine(all)

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