Does Gum Arabic Have an Antioxidant Action in Rat Kidney?

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Gum Arabic has recently been claimed to be effective in preventing gentamicin-induced acute renal failure in rats. The nephroprotection was suggested to be due to an anti-oxidant action by the gum Arabic. In the present work we tested whether treatment with gum Arabic has any effect on the concentrations of some free radical scavengers [reduced glutathione (GSH), ascorbic acid (AA), lipid peroxidation (LP), and superoxide dismutase (SOD)] in the kidneys and liver of healthy rats given gum Arabic in the drinking water at a concentration of 2.5, 5.0 or 10.0%w/v for eight consecutive days. Twenty-four hours after the last treatment, rats were killed and the above variables were measured in homogenates of kidney and liver by established spectrophotometric methods. The results indicated that the gum Arabic, at the three doses used, did not significantly affect any of the variables measured. It seems highly unlikely that gum Arabic has a palliative effect on renal failure through an antioxidant mechanism.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalRenal Failure
Volume26
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint

Gum Arabic
Antioxidants
Kidney
Free Radical Scavengers
Liver
Gentamicins
Acute Kidney Injury
Oxidants
Drinking Water
Lipid Peroxidation
Ascorbic Acid
Superoxide Dismutase
Renal Insufficiency
Glutathione

Keywords

  • Antioxidant action
  • Ascorbic acid
  • Glutathione
  • Gum Arabic
  • Kidney
  • Lipid peroxidation
  • Rat
  • Superoxide dismutase

ASJC Scopus subject areas

  • Nephrology

Cite this

Does Gum Arabic Have an Antioxidant Action in Rat Kidney? / Ali, B. H.

In: Renal Failure, Vol. 26, No. 1, 2004, p. 1-3.

Research output: Contribution to journalArticle

@article{d7d765e6d88541228b84c1c3e901c477,
title = "Does Gum Arabic Have an Antioxidant Action in Rat Kidney?",
abstract = "Gum Arabic has recently been claimed to be effective in preventing gentamicin-induced acute renal failure in rats. The nephroprotection was suggested to be due to an anti-oxidant action by the gum Arabic. In the present work we tested whether treatment with gum Arabic has any effect on the concentrations of some free radical scavengers [reduced glutathione (GSH), ascorbic acid (AA), lipid peroxidation (LP), and superoxide dismutase (SOD)] in the kidneys and liver of healthy rats given gum Arabic in the drinking water at a concentration of 2.5, 5.0 or 10.0{\%}w/v for eight consecutive days. Twenty-four hours after the last treatment, rats were killed and the above variables were measured in homogenates of kidney and liver by established spectrophotometric methods. The results indicated that the gum Arabic, at the three doses used, did not significantly affect any of the variables measured. It seems highly unlikely that gum Arabic has a palliative effect on renal failure through an antioxidant mechanism.",
keywords = "Antioxidant action, Ascorbic acid, Glutathione, Gum Arabic, Kidney, Lipid peroxidation, Rat, Superoxide dismutase",
author = "Ali, {B. H.}",
year = "2004",
doi = "10.1081/JDI-120028536",
language = "English",
volume = "26",
pages = "1--3",
journal = "Renal Failure",
issn = "0886-022X",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Does Gum Arabic Have an Antioxidant Action in Rat Kidney?

AU - Ali, B. H.

PY - 2004

Y1 - 2004

N2 - Gum Arabic has recently been claimed to be effective in preventing gentamicin-induced acute renal failure in rats. The nephroprotection was suggested to be due to an anti-oxidant action by the gum Arabic. In the present work we tested whether treatment with gum Arabic has any effect on the concentrations of some free radical scavengers [reduced glutathione (GSH), ascorbic acid (AA), lipid peroxidation (LP), and superoxide dismutase (SOD)] in the kidneys and liver of healthy rats given gum Arabic in the drinking water at a concentration of 2.5, 5.0 or 10.0%w/v for eight consecutive days. Twenty-four hours after the last treatment, rats were killed and the above variables were measured in homogenates of kidney and liver by established spectrophotometric methods. The results indicated that the gum Arabic, at the three doses used, did not significantly affect any of the variables measured. It seems highly unlikely that gum Arabic has a palliative effect on renal failure through an antioxidant mechanism.

AB - Gum Arabic has recently been claimed to be effective in preventing gentamicin-induced acute renal failure in rats. The nephroprotection was suggested to be due to an anti-oxidant action by the gum Arabic. In the present work we tested whether treatment with gum Arabic has any effect on the concentrations of some free radical scavengers [reduced glutathione (GSH), ascorbic acid (AA), lipid peroxidation (LP), and superoxide dismutase (SOD)] in the kidneys and liver of healthy rats given gum Arabic in the drinking water at a concentration of 2.5, 5.0 or 10.0%w/v for eight consecutive days. Twenty-four hours after the last treatment, rats were killed and the above variables were measured in homogenates of kidney and liver by established spectrophotometric methods. The results indicated that the gum Arabic, at the three doses used, did not significantly affect any of the variables measured. It seems highly unlikely that gum Arabic has a palliative effect on renal failure through an antioxidant mechanism.

KW - Antioxidant action

KW - Ascorbic acid

KW - Glutathione

KW - Gum Arabic

KW - Kidney

KW - Lipid peroxidation

KW - Rat

KW - Superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=1842429543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842429543&partnerID=8YFLogxK

U2 - 10.1081/JDI-120028536

DO - 10.1081/JDI-120028536

M3 - Article

C2 - 15083914

AN - SCOPUS:1842429543

VL - 26

SP - 1

EP - 3

JO - Renal Failure

JF - Renal Failure

SN - 0886-022X

IS - 1

ER -