Differences in vascular response between primary and transplanted tumours

S. B. Field, S. Needham, I. A. Burney, R. J. Maxwell, J. E. Coggle, J. R. Griffiths

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using3lP Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0. 001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors’ opinion, the most likely cause is that it results from an artefact of transplantation.

Original languageEnglish
Pages (from-to)723-726
Number of pages4
JournalBritish Journal of Cancer
Volume63
Issue number5
DOIs
Publication statusPublished - 1991

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Blood Vessels
Neoplasms
Hydralazine
Intraperitoneal Injections
Artifacts
Rodentia
Magnetic Resonance Spectroscopy
Perfusion
Transplantation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Field, S. B., Needham, S., Burney, I. A., Maxwell, R. J., Coggle, J. E., & Griffiths, J. R. (1991). Differences in vascular response between primary and transplanted tumours. British Journal of Cancer, 63(5), 723-726. https://doi.org/10.1038/bjc.1991.163

Differences in vascular response between primary and transplanted tumours. / Field, S. B.; Needham, S.; Burney, I. A.; Maxwell, R. J.; Coggle, J. E.; Griffiths, J. R.

In: British Journal of Cancer, Vol. 63, No. 5, 1991, p. 723-726.

Research output: Contribution to journalArticle

Field, SB, Needham, S, Burney, IA, Maxwell, RJ, Coggle, JE & Griffiths, JR 1991, 'Differences in vascular response between primary and transplanted tumours', British Journal of Cancer, vol. 63, no. 5, pp. 723-726. https://doi.org/10.1038/bjc.1991.163
Field, S. B. ; Needham, S. ; Burney, I. A. ; Maxwell, R. J. ; Coggle, J. E. ; Griffiths, J. R. / Differences in vascular response between primary and transplanted tumours. In: British Journal of Cancer. 1991 ; Vol. 63, No. 5. pp. 723-726.
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