Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman

M. H. Al-Maini, E. M. El-Ageb, S. S. Al-Wahaibi, Y. Al-Farsi, E. R. Richens

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Seventy female and three male Omani systemic lupus erythematosus (SLE) patients are described. At disease onset, 45 (62%) were under 20 years of age, and the remainder were between 20 and 44. Of all cases, 48% were familial. Over 5 years, the cumulative frequencies of autoantibodies was: antinuclear antibodies (ANA) 97%, anti-double-stranded DNA (anti-dsDNA) antibodies 92%, extractable nuclear antigen (ENA) antibodies 64%, antineutrophil cytoplasmic antibodies (ANCA) 58%, antiphospholipid (APL) antibodies 80%, and rheumatoid factor (Rf) 22%. Ribonucleoprotein (RNP) antibodies were found in 15/45 younger-onset and 2/28 older-onset patients (χ2= 6.63 P <0.02). The mean SLE disease activity score (SLEDAI) was 13.5 + 11.4, and the cumulative frequencies of systemic involvement were: neurological 33.8%, vascular 10.4%, musculoskeletal 53.9%, renal 50.7%, dermal 80.5%, serosal 23.9%, immunological 95%, constitutional 31.3%, and haematological 26.0%. Linear regression analysis showed that high-titre ANA were predictors for pyuria (odds ratio [OR] 9.06, P=0.01). Antiextractable nuclear antigen antibodies were predictors for disease of the neurological (OR 26.3, P=0.008) and serosal (OR 27.7, P=0.005) systems, and anti-Sm antibodies for alopecia (OR 5.93, P=0.088) and hypocomplementaemia (OR 14.6, P= 0.016). Antibodies of known diagnostic utility may also give insights into the pathogenesis of SLE.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalRheumatology International
Volume23
Issue number4
DOIs
Publication statusPublished - Jul 2003

Fingerprint

Oman
Systemic Lupus Erythematosus
Odds Ratio
Demography
Antibodies
Nuclear Antigens
Antinuclear Antibodies
Pyuria
Antineutrophil Cytoplasmic Antibodies
Antiphospholipid Antibodies
Ribonucleoproteins
Rheumatoid Factor
Alopecia
Autoantibodies
Blood Vessels
Anti-Idiotypic Antibodies
Linear Models
Regression Analysis
Kidney
Skin

Keywords

  • Arab
  • Autoimmunity
  • Oman
  • Organ involvement
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman. / Al-Maini, M. H.; El-Ageb, E. M.; Al-Wahaibi, S. S.; Al-Farsi, Y.; Richens, E. R.

In: Rheumatology International, Vol. 23, No. 4, 07.2003, p. 186-191.

Research output: Contribution to journalArticle

Al-Maini, M. H. ; El-Ageb, E. M. ; Al-Wahaibi, S. S. ; Al-Farsi, Y. ; Richens, E. R. / Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman. In: Rheumatology International. 2003 ; Vol. 23, No. 4. pp. 186-191.
@article{ed2dda1767b842df91cd5bb61ce2a9ba,
title = "Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman",
abstract = "Seventy female and three male Omani systemic lupus erythematosus (SLE) patients are described. At disease onset, 45 (62{\%}) were under 20 years of age, and the remainder were between 20 and 44. Of all cases, 48{\%} were familial. Over 5 years, the cumulative frequencies of autoantibodies was: antinuclear antibodies (ANA) 97{\%}, anti-double-stranded DNA (anti-dsDNA) antibodies 92{\%}, extractable nuclear antigen (ENA) antibodies 64{\%}, antineutrophil cytoplasmic antibodies (ANCA) 58{\%}, antiphospholipid (APL) antibodies 80{\%}, and rheumatoid factor (Rf) 22{\%}. Ribonucleoprotein (RNP) antibodies were found in 15/45 younger-onset and 2/28 older-onset patients (χ2= 6.63 P <0.02). The mean SLE disease activity score (SLEDAI) was 13.5 + 11.4, and the cumulative frequencies of systemic involvement were: neurological 33.8{\%}, vascular 10.4{\%}, musculoskeletal 53.9{\%}, renal 50.7{\%}, dermal 80.5{\%}, serosal 23.9{\%}, immunological 95{\%}, constitutional 31.3{\%}, and haematological 26.0{\%}. Linear regression analysis showed that high-titre ANA were predictors for pyuria (odds ratio [OR] 9.06, P=0.01). Antiextractable nuclear antigen antibodies were predictors for disease of the neurological (OR 26.3, P=0.008) and serosal (OR 27.7, P=0.005) systems, and anti-Sm antibodies for alopecia (OR 5.93, P=0.088) and hypocomplementaemia (OR 14.6, P= 0.016). Antibodies of known diagnostic utility may also give insights into the pathogenesis of SLE.",
keywords = "Arab, Autoimmunity, Oman, Organ involvement, Systemic lupus erythematosus",
author = "Al-Maini, {M. H.} and El-Ageb, {E. M.} and Al-Wahaibi, {S. S.} and Y. Al-Farsi and Richens, {E. R.}",
year = "2003",
month = "7",
doi = "10.1007/s00296-003-0303-6",
language = "English",
volume = "23",
pages = "186--191",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman

AU - Al-Maini, M. H.

AU - El-Ageb, E. M.

AU - Al-Wahaibi, S. S.

AU - Al-Farsi, Y.

AU - Richens, E. R.

PY - 2003/7

Y1 - 2003/7

N2 - Seventy female and three male Omani systemic lupus erythematosus (SLE) patients are described. At disease onset, 45 (62%) were under 20 years of age, and the remainder were between 20 and 44. Of all cases, 48% were familial. Over 5 years, the cumulative frequencies of autoantibodies was: antinuclear antibodies (ANA) 97%, anti-double-stranded DNA (anti-dsDNA) antibodies 92%, extractable nuclear antigen (ENA) antibodies 64%, antineutrophil cytoplasmic antibodies (ANCA) 58%, antiphospholipid (APL) antibodies 80%, and rheumatoid factor (Rf) 22%. Ribonucleoprotein (RNP) antibodies were found in 15/45 younger-onset and 2/28 older-onset patients (χ2= 6.63 P <0.02). The mean SLE disease activity score (SLEDAI) was 13.5 + 11.4, and the cumulative frequencies of systemic involvement were: neurological 33.8%, vascular 10.4%, musculoskeletal 53.9%, renal 50.7%, dermal 80.5%, serosal 23.9%, immunological 95%, constitutional 31.3%, and haematological 26.0%. Linear regression analysis showed that high-titre ANA were predictors for pyuria (odds ratio [OR] 9.06, P=0.01). Antiextractable nuclear antigen antibodies were predictors for disease of the neurological (OR 26.3, P=0.008) and serosal (OR 27.7, P=0.005) systems, and anti-Sm antibodies for alopecia (OR 5.93, P=0.088) and hypocomplementaemia (OR 14.6, P= 0.016). Antibodies of known diagnostic utility may also give insights into the pathogenesis of SLE.

AB - Seventy female and three male Omani systemic lupus erythematosus (SLE) patients are described. At disease onset, 45 (62%) were under 20 years of age, and the remainder were between 20 and 44. Of all cases, 48% were familial. Over 5 years, the cumulative frequencies of autoantibodies was: antinuclear antibodies (ANA) 97%, anti-double-stranded DNA (anti-dsDNA) antibodies 92%, extractable nuclear antigen (ENA) antibodies 64%, antineutrophil cytoplasmic antibodies (ANCA) 58%, antiphospholipid (APL) antibodies 80%, and rheumatoid factor (Rf) 22%. Ribonucleoprotein (RNP) antibodies were found in 15/45 younger-onset and 2/28 older-onset patients (χ2= 6.63 P <0.02). The mean SLE disease activity score (SLEDAI) was 13.5 + 11.4, and the cumulative frequencies of systemic involvement were: neurological 33.8%, vascular 10.4%, musculoskeletal 53.9%, renal 50.7%, dermal 80.5%, serosal 23.9%, immunological 95%, constitutional 31.3%, and haematological 26.0%. Linear regression analysis showed that high-titre ANA were predictors for pyuria (odds ratio [OR] 9.06, P=0.01). Antiextractable nuclear antigen antibodies were predictors for disease of the neurological (OR 26.3, P=0.008) and serosal (OR 27.7, P=0.005) systems, and anti-Sm antibodies for alopecia (OR 5.93, P=0.088) and hypocomplementaemia (OR 14.6, P= 0.016). Antibodies of known diagnostic utility may also give insights into the pathogenesis of SLE.

KW - Arab

KW - Autoimmunity

KW - Oman

KW - Organ involvement

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=0041658929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041658929&partnerID=8YFLogxK

U2 - 10.1007/s00296-003-0303-6

DO - 10.1007/s00296-003-0303-6

M3 - Article

VL - 23

SP - 186

EP - 191

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 4

ER -