Congenital fiber-type disproportion myopathy with type I fiber predominance and type II fiber smallness and atrophy - A sterological analysis

T. V. Rao, R. L. Koul, I. M. Inuwa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Congenital myopathy with fiber-type disproportion is an established disorder, where type I fibers predominate with smallness of the same type. We report a family with three siblings (12-year-old boy, 9-year-old girl, and 6-year-old boy) with clinical features of congenital myopathy, where muscle biopsy in the eldest sib showed fiber-type disproportion. Type I fibers predominated with small and atrophic type II fibers which is unusual, especially when the child did not have any other clinical or biochemical abnormality to account for this type of variation. Further, a stereological analysis highlighted the differences with regards to number, size and even volume of the fiber types. A 3-dimensional concept is proposed for this morphological abnormality.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalClinical Neuropathology
Volume24
Issue number1
Publication statusPublished - Jan 2005

Fingerprint

Congenital Structural Myopathies
Atrophy
Myotonia Congenita
Siblings
Biopsy
Muscles

Keywords

  • Congenital
  • Disproportion
  • Muscle fiber
  • Myopathy
  • Stereology

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Congenital fiber-type disproportion myopathy with type I fiber predominance and type II fiber smallness and atrophy - A sterological analysis. / Rao, T. V.; Koul, R. L.; Inuwa, I. M.

In: Clinical Neuropathology, Vol. 24, No. 1, 01.2005, p. 26-31.

Research output: Contribution to journalArticle

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