Comparative pharmacokinetics of salicylate in camels, sheep and goats

This study compared some pharmacokinetic parameters of DL-lysine-acetyl salicylate administered intravenously (i.v.) and intramuscularly (i.m.) at a dose of 20 mg/kg in camels, sheep and goats. The data was analyzed using a non-compartmental model. In camels, sheep and goats given the drug i.v., the t_1/2 values were 43.1, 31.2 and 27.3; the clearance (CI) values were 203.7, 261.1, and 280.4 ml/h/kg, while the area under the curve (AUC) were 100.1, 106.9 and 110.5 mg.h/L, respectively. In camels, sheep and goats given the drug by the i.m. route the mean peak plasma concentration (C_max) were 0.94, 1.44 and 1.74 mg/ml, and the time to reach C_max (t_max) were 2.94, 2.57 and 2.43h, respectively. The t_1/2 values were 48.9, 38.2 and 36.0 min; the clearance (CI) values were 261.3, 297.4 and 306.4 ml/h/kg, while the area under the curve (AUC) were 101.6, 117.3 and 123.7 mg.h/L, respectively. The drug bioavailability (F) in camels, sheep and goats were 71.3, 78.4 and 79.4% respectively. These findings suggest that the rate of absorption and elimination of the salicylate is slower in camels than in sheep and goats.