TY - JOUR
T1 - Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait
T2 - A Prospective Study
AU - Abul, A.
AU - Onadeko, B. O.
AU - Khadadah, M. E.
AU - Behbehani, N.
AU - Cerna, M.
AU - Cherian, J. M.
AU - Maradni, N.
AU - Jayakrishnan, B.
PY - 2004
Y1 - 2004
N2 - Objective: To report our experience of the clinicopathological patterns of diffuse parenchymal lung disease (DPLD). Subjects and Methods: Over a 4-year period, 75 patients (41 males, 34 females), aged 13-76 years, who were referred to Mubarak Al-Kabeer and the Chest Diseases Hospitals, Kuwait with a diagnosis of diffuse lung disease, were included in the study. After a comprehensive history and physical examination, further investigations were done, including hematological and immunological profiles, sputum and bronchoalveolar lavage fluid examination, chest radiograph, high resolution computed tomography (HRCT), pulmonary function test and lung biopsy. Results: Of the 75 patients 60 (80%) were over 40 years of age. The duration of symptoms in 34 patients (45%) was less than 6 months and longer than 1 year in 28 (37.7%) patients. Twenty-five of the patients were cigarette smokers. The mean forced lung capacity (FVC), total lung capacity and diffusing capacity for carbon monoxide were less than 60% of the predicted values in most patients. There was a significant difference in mean FVC value between smokers and nonsmokers (p < 0.05). The HRCT findings were at an advanced stage in 65 patients, with additional honeycombing in 21 of the 65 patients. Idiopathic pulmonary fibrosis was the most common cause of DPLD, occurring in 52 patients, followed by sarcoidosis and collagen vascular diseases. Conclusion: DPLD was observed predominantly in middle aged and elderly patients, due probably to increasing industrialization in the country. The role of cigarette smoking as a contributory factor remains unclear.
AB - Objective: To report our experience of the clinicopathological patterns of diffuse parenchymal lung disease (DPLD). Subjects and Methods: Over a 4-year period, 75 patients (41 males, 34 females), aged 13-76 years, who were referred to Mubarak Al-Kabeer and the Chest Diseases Hospitals, Kuwait with a diagnosis of diffuse lung disease, were included in the study. After a comprehensive history and physical examination, further investigations were done, including hematological and immunological profiles, sputum and bronchoalveolar lavage fluid examination, chest radiograph, high resolution computed tomography (HRCT), pulmonary function test and lung biopsy. Results: Of the 75 patients 60 (80%) were over 40 years of age. The duration of symptoms in 34 patients (45%) was less than 6 months and longer than 1 year in 28 (37.7%) patients. Twenty-five of the patients were cigarette smokers. The mean forced lung capacity (FVC), total lung capacity and diffusing capacity for carbon monoxide were less than 60% of the predicted values in most patients. There was a significant difference in mean FVC value between smokers and nonsmokers (p < 0.05). The HRCT findings were at an advanced stage in 65 patients, with additional honeycombing in 21 of the 65 patients. Idiopathic pulmonary fibrosis was the most common cause of DPLD, occurring in 52 patients, followed by sarcoidosis and collagen vascular diseases. Conclusion: DPLD was observed predominantly in middle aged and elderly patients, due probably to increasing industrialization in the country. The role of cigarette smoking as a contributory factor remains unclear.
KW - Cigarette smoking
KW - High resolution computed tomography
KW - Lung biopsy
KW - Pulmonary fibrosis
KW - Pulmonary function test
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U2 - 10.1159/000075633
DO - 10.1159/000075633
M3 - Article
C2 - 14755139
AN - SCOPUS:1042266491
SN - 1011-7571
VL - 13
SP - 78
EP - 83
JO - Medical Principles and Practice
JF - Medical Principles and Practice
IS - 2
ER -