Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait

A Prospective Study

A. Abul, B. O. Onadeko, M. E. Khadadah, N. Behbehani, M. Cerna, J. M. Cherian, N. Maradni, B. Jayakrishnan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To report our experience of the clinicopathological patterns of diffuse parenchymal lung disease (DPLD). Subjects and Methods: Over a 4-year period, 75 patients (41 males, 34 females), aged 13-76 years, who were referred to Mubarak Al-Kabeer and the Chest Diseases Hospitals, Kuwait with a diagnosis of diffuse lung disease, were included in the study. After a comprehensive history and physical examination, further investigations were done, including hematological and immunological profiles, sputum and bronchoalveolar lavage fluid examination, chest radiograph, high resolution computed tomography (HRCT), pulmonary function test and lung biopsy. Results: Of the 75 patients 60 (80%) were over 40 years of age. The duration of symptoms in 34 patients (45%) was less than 6 months and longer than 1 year in 28 (37.7%) patients. Twenty-five of the patients were cigarette smokers. The mean forced lung capacity (FVC), total lung capacity and diffusing capacity for carbon monoxide were less than 60% of the predicted values in most patients. There was a significant difference in mean FVC value between smokers and nonsmokers (p <0.05). The HRCT findings were at an advanced stage in 65 patients, with additional honeycombing in 21 of the 65 patients. Idiopathic pulmonary fibrosis was the most common cause of DPLD, occurring in 52 patients, followed by sarcoidosis and collagen vascular diseases. Conclusion: DPLD was observed predominantly in middle aged and elderly patients, due probably to increasing industrialization in the country. The role of cigarette smoking as a contributory factor remains unclear.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalMedical Principles and Practice
Volume13
Issue number2
DOIs
Publication statusPublished - 2004

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Kuwait
Interstitial Lung Diseases
Prospective Studies
Thorax
Tomography
Lung Volume Measurements
Total Lung Capacity
Collagen Diseases
Idiopathic Pulmonary Fibrosis
Respiratory Function Tests
Bronchoalveolar Lavage Fluid
Carbon Monoxide
Sarcoidosis
Sputum
Vascular Diseases
Tobacco Products
Lung Diseases
Physical Examination
Smoking
History

Keywords

  • Cigarette smoking
  • High resolution computed tomography
  • Lung biopsy
  • Pulmonary fibrosis
  • Pulmonary function test

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait : A Prospective Study. / Abul, A.; Onadeko, B. O.; Khadadah, M. E.; Behbehani, N.; Cerna, M.; Cherian, J. M.; Maradni, N.; Jayakrishnan, B.

In: Medical Principles and Practice, Vol. 13, No. 2, 2004, p. 78-83.

Research output: Contribution to journalArticle

Abul, A, Onadeko, BO, Khadadah, ME, Behbehani, N, Cerna, M, Cherian, JM, Maradni, N & Jayakrishnan, B 2004, 'Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait: A Prospective Study', Medical Principles and Practice, vol. 13, no. 2, pp. 78-83. https://doi.org/10.1159/000075633
Abul, A. ; Onadeko, B. O. ; Khadadah, M. E. ; Behbehani, N. ; Cerna, M. ; Cherian, J. M. ; Maradni, N. ; Jayakrishnan, B. / Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait : A Prospective Study. In: Medical Principles and Practice. 2004 ; Vol. 13, No. 2. pp. 78-83.
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AB - Objective: To report our experience of the clinicopathological patterns of diffuse parenchymal lung disease (DPLD). Subjects and Methods: Over a 4-year period, 75 patients (41 males, 34 females), aged 13-76 years, who were referred to Mubarak Al-Kabeer and the Chest Diseases Hospitals, Kuwait with a diagnosis of diffuse lung disease, were included in the study. After a comprehensive history and physical examination, further investigations were done, including hematological and immunological profiles, sputum and bronchoalveolar lavage fluid examination, chest radiograph, high resolution computed tomography (HRCT), pulmonary function test and lung biopsy. Results: Of the 75 patients 60 (80%) were over 40 years of age. The duration of symptoms in 34 patients (45%) was less than 6 months and longer than 1 year in 28 (37.7%) patients. Twenty-five of the patients were cigarette smokers. The mean forced lung capacity (FVC), total lung capacity and diffusing capacity for carbon monoxide were less than 60% of the predicted values in most patients. There was a significant difference in mean FVC value between smokers and nonsmokers (p <0.05). The HRCT findings were at an advanced stage in 65 patients, with additional honeycombing in 21 of the 65 patients. Idiopathic pulmonary fibrosis was the most common cause of DPLD, occurring in 52 patients, followed by sarcoidosis and collagen vascular diseases. Conclusion: DPLD was observed predominantly in middle aged and elderly patients, due probably to increasing industrialization in the country. The role of cigarette smoking as a contributory factor remains unclear.

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