Citrus fruits and neurodegenration

C. Dhanalakshmi, A. Justin Thenmozhi, T. Manivasagam, M. Mohamed Essa, M. A.S. Khan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neurodegenerative diseases (NDDs) including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) are mainly affecting the aged population worldwide. According to the report of the World Health Organization, the morbidity due to NDDs will be second highest cause of death in 2040. PD is the second most common progressive NDD after AD that is characterized by resting tremor, rigidity, postural abnormalities, stooped posture, bradykinesia, akinesia and festinating gait. Symptomatic and effective treatment of PD in modern medicine is by the supplementation of the dopamine in the form of L-dopa. However, long term administration typically leads to motor complications, such as L-dopa induced dyskinesia. Current pharmacological therapies for the disease are inadequate. Unfortunately, other strategies such as neural transplantation and stem cell transplantation remain in experimental stage. The pathogenesis of PD is multifactorial with toxic reactions including inflammation the glutamatergic toxicity, the dysfunction of mitochondrial activity and of the ubiquitin/proteasome system, the activation of apoptosis pathways, the elevation of iron and nitric oxide, the alteration of the homeostasis of antioxidants/oxidants. Numerous cellular, animal and human studies have delineated the anti-parkinsonic effects of citrus fruits owning to their active components. Increased consumption of citrus fruits is associated with higher antioxidant status and phytochemical constituents, thus helpful against oxidative stress, mitochondrial dysfunction, inflammation and apoptosis that play an important role in the cause and progression of PD.The multifactorial etiology of PD suggests that drugs with multiple targets could have therapeutical potential for these pathologies.

Original languageEnglish
Title of host publicationFood and Parkinson's Disease
PublisherNova Science Publishers, Inc.
Pages95-113
Number of pages19
ISBN (Electronic)9781634857543
ISBN (Print)9781634857369
Publication statusPublished - Jan 1 2016

Fingerprint

Citrus
Parkinson Disease
Neurodegenerative Diseases
Levodopa
Alzheimer Disease
Antioxidants
Neurologic Gait Disorders
Apoptosis
Inflammation
Hypokinesia
Modern 1601-history
Neural Stem Cells
Poisons
Huntington Disease
Dyskinesias
Phytochemicals
Stem Cell Transplantation
Tremor
Proteasome Endopeptidase Complex
Ubiquitin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dhanalakshmi, C., Justin Thenmozhi, A., Manivasagam, T., Mohamed Essa, M., & Khan, M. A. S. (2016). Citrus fruits and neurodegenration. In Food and Parkinson's Disease (pp. 95-113). Nova Science Publishers, Inc..

Citrus fruits and neurodegenration. / Dhanalakshmi, C.; Justin Thenmozhi, A.; Manivasagam, T.; Mohamed Essa, M.; Khan, M. A.S.

Food and Parkinson's Disease. Nova Science Publishers, Inc., 2016. p. 95-113.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dhanalakshmi, C, Justin Thenmozhi, A, Manivasagam, T, Mohamed Essa, M & Khan, MAS 2016, Citrus fruits and neurodegenration. in Food and Parkinson's Disease. Nova Science Publishers, Inc., pp. 95-113.
Dhanalakshmi C, Justin Thenmozhi A, Manivasagam T, Mohamed Essa M, Khan MAS. Citrus fruits and neurodegenration. In Food and Parkinson's Disease. Nova Science Publishers, Inc. 2016. p. 95-113
Dhanalakshmi, C. ; Justin Thenmozhi, A. ; Manivasagam, T. ; Mohamed Essa, M. ; Khan, M. A.S. / Citrus fruits and neurodegenration. Food and Parkinson's Disease. Nova Science Publishers, Inc., 2016. pp. 95-113
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