Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma

B. O. Onadeko, M. E. Khadadah, C. I. Ezeamnzie, R. Marouf, M. Zubaid, N. Maradni, B. Jayakrishnan, A. Memon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Exercise-induced asthma (EIA) is increasingly encountered among school children in Kuwait. Available evidence has shown that inflammatory mediators may be involved in the pathogenesis of EIA. Studies on release of inflammatory mediators have been carried out in adult patients with asthma in Kuwait, but no study on EIA involving children has taken place in this region. Objective: To investigate changes in the concentration of some of the mediators involved in EIA in adolescent school children, Using exercise challenge. Design: Prospective, case control study. Setting: Respiratory and Cardiology units Mubarak Hospital, Kuwait, between January and June 2001. Subjects: Nine EIA and 14 non-EIA and 10 normal control subjects, designated as groups one, two and three aged between 13 and 17 years, who were non-smokers, were enrolled for the study Main Outcome Measures: Blood eosinophils (EOS), eosinophil cationic protein (ECP) and tryptase were estimated pre-exercise, 5 and 30 minutes after exercise. Spirometry was measured at the same period. Results: In group one, ECP and tryptase levels fell after exercise, but significant difference in the levels were obtained only in tryptase between pre-exercise and 30 minutes after exercise. (4.1 μg/L Vs 3.8 μg/L) P

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalEast African Medical Journal
Volume81
Issue number1
Publication statusPublished - Jan 2004

Fingerprint

Exercise-Induced Asthma
Eosinophil Cationic Protein
Tryptases
Blood
Exercise
Kuwait
Cardiology
Asthma
Hospital Units
Spirometry
Eosinophils
Case-Control Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Onadeko, B. O., Khadadah, M. E., Ezeamnzie, C. I., Marouf, R., Zubaid, M., Maradni, N., ... Memon, A. (2004). Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma. East African Medical Journal, 81(1), 27-33.

Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma. / Onadeko, B. O.; Khadadah, M. E.; Ezeamnzie, C. I.; Marouf, R.; Zubaid, M.; Maradni, N.; Jayakrishnan, B.; Memon, A.

In: East African Medical Journal, Vol. 81, No. 1, 01.2004, p. 27-33.

Research output: Contribution to journalArticle

Onadeko, BO, Khadadah, ME, Ezeamnzie, CI, Marouf, R, Zubaid, M, Maradni, N, Jayakrishnan, B & Memon, A 2004, 'Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma', East African Medical Journal, vol. 81, no. 1, pp. 27-33.
Onadeko, B. O. ; Khadadah, M. E. ; Ezeamnzie, C. I. ; Marouf, R. ; Zubaid, M. ; Maradni, N. ; Jayakrishnan, B. ; Memon, A. / Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma. In: East African Medical Journal. 2004 ; Vol. 81, No. 1. pp. 27-33.
@article{3b6a21a5ce4f412085d0197275d7763f,
title = "Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma",
abstract = "Background: Exercise-induced asthma (EIA) is increasingly encountered among school children in Kuwait. Available evidence has shown that inflammatory mediators may be involved in the pathogenesis of EIA. Studies on release of inflammatory mediators have been carried out in adult patients with asthma in Kuwait, but no study on EIA involving children has taken place in this region. Objective: To investigate changes in the concentration of some of the mediators involved in EIA in adolescent school children, Using exercise challenge. Design: Prospective, case control study. Setting: Respiratory and Cardiology units Mubarak Hospital, Kuwait, between January and June 2001. Subjects: Nine EIA and 14 non-EIA and 10 normal control subjects, designated as groups one, two and three aged between 13 and 17 years, who were non-smokers, were enrolled for the study Main Outcome Measures: Blood eosinophils (EOS), eosinophil cationic protein (ECP) and tryptase were estimated pre-exercise, 5 and 30 minutes after exercise. Spirometry was measured at the same period. Results: In group one, ECP and tryptase levels fell after exercise, but significant difference in the levels were obtained only in tryptase between pre-exercise and 30 minutes after exercise. (4.1 μg/L Vs 3.8 μg/L) P",
author = "Onadeko, {B. O.} and Khadadah, {M. E.} and Ezeamnzie, {C. I.} and R. Marouf and M. Zubaid and N. Maradni and B. Jayakrishnan and A. Memon",
year = "2004",
month = "1",
language = "English",
volume = "81",
pages = "27--33",
journal = "East African Medical Journal",
issn = "0012-835X",
publisher = "East African Medical Association",
number = "1",

}

TY - JOUR

T1 - Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma

AU - Onadeko, B. O.

AU - Khadadah, M. E.

AU - Ezeamnzie, C. I.

AU - Marouf, R.

AU - Zubaid, M.

AU - Maradni, N.

AU - Jayakrishnan, B.

AU - Memon, A.

PY - 2004/1

Y1 - 2004/1

N2 - Background: Exercise-induced asthma (EIA) is increasingly encountered among school children in Kuwait. Available evidence has shown that inflammatory mediators may be involved in the pathogenesis of EIA. Studies on release of inflammatory mediators have been carried out in adult patients with asthma in Kuwait, but no study on EIA involving children has taken place in this region. Objective: To investigate changes in the concentration of some of the mediators involved in EIA in adolescent school children, Using exercise challenge. Design: Prospective, case control study. Setting: Respiratory and Cardiology units Mubarak Hospital, Kuwait, between January and June 2001. Subjects: Nine EIA and 14 non-EIA and 10 normal control subjects, designated as groups one, two and three aged between 13 and 17 years, who were non-smokers, were enrolled for the study Main Outcome Measures: Blood eosinophils (EOS), eosinophil cationic protein (ECP) and tryptase were estimated pre-exercise, 5 and 30 minutes after exercise. Spirometry was measured at the same period. Results: In group one, ECP and tryptase levels fell after exercise, but significant difference in the levels were obtained only in tryptase between pre-exercise and 30 minutes after exercise. (4.1 μg/L Vs 3.8 μg/L) P

AB - Background: Exercise-induced asthma (EIA) is increasingly encountered among school children in Kuwait. Available evidence has shown that inflammatory mediators may be involved in the pathogenesis of EIA. Studies on release of inflammatory mediators have been carried out in adult patients with asthma in Kuwait, but no study on EIA involving children has taken place in this region. Objective: To investigate changes in the concentration of some of the mediators involved in EIA in adolescent school children, Using exercise challenge. Design: Prospective, case control study. Setting: Respiratory and Cardiology units Mubarak Hospital, Kuwait, between January and June 2001. Subjects: Nine EIA and 14 non-EIA and 10 normal control subjects, designated as groups one, two and three aged between 13 and 17 years, who were non-smokers, were enrolled for the study Main Outcome Measures: Blood eosinophils (EOS), eosinophil cationic protein (ECP) and tryptase were estimated pre-exercise, 5 and 30 minutes after exercise. Spirometry was measured at the same period. Results: In group one, ECP and tryptase levels fell after exercise, but significant difference in the levels were obtained only in tryptase between pre-exercise and 30 minutes after exercise. (4.1 μg/L Vs 3.8 μg/L) P

UR - http://www.scopus.com/inward/record.url?scp=3042824096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042824096&partnerID=8YFLogxK

M3 - Article

VL - 81

SP - 27

EP - 33

JO - East African Medical Journal

JF - East African Medical Journal

SN - 0012-835X

IS - 1

ER -