Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Abdullah M S Al-Hatmi, Abdullah Balkhair, Ibrahim Al-Busaidi, Marcelo Sandoval-Denis, Saif Al-Housni, Hashim Ba Taher, Asmaa Hamdan Al Shehhi, Sameer Raniga, Maha Al Shaibi, Turkiya Al Siyabi, Jacques F Meis, G Sybren de Hoog, Ahmed Al-Rawahi, Zakariya Al Muharrmi, Ahmed Al-Harrasi, Badriya Al Adawi

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Abstract

Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

Original languageEnglish
JournalJournal of Fungi
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 12 2021

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