Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2

Ruth J. Reiss-Gutfreund, Norbert R. Nowotny, Viktor Dostal, Heinrich Wrba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In vitro, LLT cells sustain HSV-2 replication without evidence of lysis. Simultaneously, multiplication of the cells is stimulated. These xenogenized cells were tested for their immunopotentiating capacity: three-step immunization with xenogenized viable cells conferred significantly augmented transplantation resistance to a challenge graft with 4 × 104 intact LLT cells. Latency periods preceding tumor formation were increased and 15% of the mice failed to form primary tumors. Metastatis was likewise decreased and 25% of the mice had healthy lungs. Immunopotentiation, however, did not suffice to significantly protect against a challenge with 6 × 104 intact cells. The presence of virus-specific neoantigens on HSV-2-infected vaiable cells was demonstrated by the progressively increasing number of rejections of 4 × 104 xenogenized cells during the successive immunization steps. Immunization with non-viable LLT cells did not augment resistance to challenge.

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Volume18
Issue number6
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2'. Together they form a unique fingerprint.

  • Cite this