TY - JOUR
T1 - Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2
AU - Reiss-Gutfreund, Ruth J.
AU - Nowotny, Norbert R.
AU - Dostal, Viktor
AU - Wrba, Heinrich
PY - 1982/6
Y1 - 1982/6
N2 - In vitro, LLT cells sustain HSV-2 replication without evidence of lysis. Simultaneously, multiplication of the cells is stimulated. These xenogenized cells were tested for their immunopotentiating capacity: three-step immunization with xenogenized viable cells conferred significantly augmented transplantation resistance to a challenge graft with 4 × 104 intact LLT cells. Latency periods preceding tumor formation were increased and 15% of the mice failed to form primary tumors. Metastatis was likewise decreased and 25% of the mice had healthy lungs. Immunopotentiation, however, did not suffice to significantly protect against a challenge with 6 × 104 intact cells. The presence of virus-specific neoantigens on HSV-2-infected vaiable cells was demonstrated by the progressively increasing number of rejections of 4 × 104 xenogenized cells during the successive immunization steps. Immunization with non-viable LLT cells did not augment resistance to challenge.
AB - In vitro, LLT cells sustain HSV-2 replication without evidence of lysis. Simultaneously, multiplication of the cells is stimulated. These xenogenized cells were tested for their immunopotentiating capacity: three-step immunization with xenogenized viable cells conferred significantly augmented transplantation resistance to a challenge graft with 4 × 104 intact LLT cells. Latency periods preceding tumor formation were increased and 15% of the mice failed to form primary tumors. Metastatis was likewise decreased and 25% of the mice had healthy lungs. Immunopotentiation, however, did not suffice to significantly protect against a challenge with 6 × 104 intact cells. The presence of virus-specific neoantigens on HSV-2-infected vaiable cells was demonstrated by the progressively increasing number of rejections of 4 × 104 xenogenized cells during the successive immunization steps. Immunization with non-viable LLT cells did not augment resistance to challenge.
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U2 - 10.1016/0277-5379(82)90221-8
DO - 10.1016/0277-5379(82)90221-8
M3 - Article
C2 - 6288391
AN - SCOPUS:0019995171
SN - 0277-5379
VL - 18
SP - 523
EP - 531
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
IS - 6
ER -