Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2

Ruth J. Reiss-Gutfreund, Norbert R. Nowotny, Viktor Dostal, Heinrich Wrba

Research output: Contribution to journalArticle

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Abstract

In vitro, LLT cells sustain HSV-2 replication without evidence of lysis. Simultaneously, multiplication of the cells is stimulated. These xenogenized cells were tested for their immunopotentiating capacity: three-step immunization with xenogenized viable cells conferred significantly augmented transplantation resistance to a challenge graft with 4 × 104 intact LLT cells. Latency periods preceding tumor formation were increased and 15% of the mice failed to form primary tumors. Metastatis was likewise decreased and 25% of the mice had healthy lungs. Immunopotentiation, however, did not suffice to significantly protect against a challenge with 6 × 104 intact cells. The presence of virus-specific neoantigens on HSV-2-infected vaiable cells was demonstrated by the progressively increasing number of rejections of 4 × 104 xenogenized cells during the successive immunization steps. Immunization with non-viable LLT cells did not augment resistance to challenge.

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Volume18
Issue number6
DOIs
Publication statusPublished - 1982

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Lewis Lung Carcinoma
Human Herpesvirus 2
Infection
Immunization
Neoplasms
Transplantation
Cell Proliferation
Viruses
Transplants
Lung

ASJC Scopus subject areas

  • Oncology

Cite this

Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2. / Reiss-Gutfreund, Ruth J.; Nowotny, Norbert R.; Dostal, Viktor; Wrba, Heinrich.

In: European Journal of Cancer and Clinical Oncology, Vol. 18, No. 6, 1982, p. 523-531.

Research output: Contribution to journalArticle

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